Placeholder image of a protein
Icon representing a puzzle

909: Bonus CASP11 T0787 HIV-1 Env Symmetry Puzzle

Closed since over 8 years ago

Advanced Overall Prediction Symmetry CASP11

Summary


Created
June 05, 2014
Expires
Max points
100
Description

The CASP organizers have told us that this HIV-1 Env protein is a trimer, so we are posting a Bonus Round for T0787 as a symmetric trimer! We've provided you with a RosettaServer model to start with. More info in the puzzle comments about different possible folds.

Top groups


  1. Avatar for Anthropic Dreams 100 pts. 16,063
  2. Avatar for Beta Folders 2. Beta Folders 81 pts. 15,615
  3. Avatar for L'Alliance Francophone 3. L'Alliance Francophone 64 pts. 15,493
  4. Avatar for Go Science 4. Go Science 50 pts. 15,366
  5. Avatar for Gargleblasters 5. Gargleblasters 39 pts. 15,343
  6. Avatar for Void Crushers 6. Void Crushers 30 pts. 15,233
  7. Avatar for Deleted group 7. Deleted group pts. 15,046
  8. Avatar for Deleted group 8. Deleted group pts. 14,996
  9. Avatar for Hun-Magyar Csapat 9. Hun-Magyar Csapat 12 pts. 14,940
  10. Avatar for Contenders 10. Contenders 9 pts. 14,831

  1. Avatar for BitSpawn
    1. BitSpawn Lv 1
    100 pts. 16,063
  2. Avatar for auntdeen 2. auntdeen Lv 1 98 pts. 15,832
  3. Avatar for retiredmichael 3. retiredmichael Lv 1 95 pts. 15,615
  4. Avatar for gmn 4. gmn Lv 1 93 pts. 15,508
  5. Avatar for Galaxie 5. Galaxie Lv 1 90 pts. 15,495
  6. Avatar for Museka 6. Museka Lv 1 88 pts. 15,493
  7. Avatar for karstenw 7. karstenw Lv 1 86 pts. 15,476
  8. Avatar for frood66 8. frood66 Lv 1 83 pts. 15,343
  9. Avatar for LociOiling 9. LociOiling Lv 1 81 pts. 15,329
  10. Avatar for KarenCH 10. KarenCH Lv 1 79 pts. 15,320

Comments


beta_helix Staff Lv 1

We provided you with Model 1 predicted by Robetta, but you can see that Robetta Models 3-5 also formed a trimer, but they are arranged differently:

http://rosettaserver.bakerlab.org/results.jsp?id=48566

Feel free to use those packing arrangements as inspirations for your own!

NOTE the short deadline on this Bonus CASP11 Puzzle, due to Target T0787 being due early on June 11th.
______________

More information about this CASP Target:
"CASP targets T0787 (gp41) and T0788 (gp120) are two parts of the HIV-1 Env complex, comprising three gp120 subunits and three gp41 subunits."
http://predictioncenter.org/casp11/target.cgi?id=36