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778: 58 Residue D2 Tetramer Design

Closed since about 9 years ago

Intermediate Overall Design Symmetry

Summary


Created
September 12, 2013
Expires
Max points
100
Description

This is a 58 residue tetramer design puzzle with D2 symmetry; there will be four symmetric chains to manage. Note that the score of a symmetric protein relies not only on how well-folded each chain is, but also on how well the chains interface together. See the blog post about this for more information. There are 2 filters enabled on this puzzle: the Residue IE Score monitors that all PHY, TYR, and TRP residues are scoring well, and the Core Exists filter checks that at least 30% of the residues are buried in the core of your design. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions.

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