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616: Symmetric Beta Core Design Puzzle 2

Closed since about 10 years ago

Intermediate Overall Design Symmetry

Summary


Created
August 10, 2012
Expires
Max points
100
Description

This is part two of the small symmetric dimer design puzzle that uses a known structure as a starting point. We're interested to see what sort of designs you can come up with that respect the dimer symmetry, and fold around a central beta sheet. For the previous WXCXW puzzle we gave you an extended 20 residue chain at the C-terminus. We’ve moved that chain to the N terminus for this puzzle, which should allow for very different sorts of designs. Remember, a symmetric protein relies not only on how well folded each part is, but also on how well they interface together!

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