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614: CASP10 Refinement Puzzle: TR724

Closed since about 10 years ago

Intermediate Overall Prediction

Summary


Created
August 03, 2012
Expires
Max points
100
Description

The twenty-third CASP10 Refinement Target was the best server prediction for target T0724, generated by the slbio server. We've been told that ~60% of this model matches the native, so you'll need to significantly change the starting model. More info in the puzzle comments.

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Comments


beta_helix Staff Lv 1

This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=209

The CASP10 organizers gave us this hint:

"Starting model GDT_TS=60."

GDT_TS=60 essentially means that 60% of the model superimposes correctly onto the native structure:

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 35, 44, 53, 63 & 87 are highly predicted to be part of a sheet. However, the Alanines at residues 11 & 49-50 are predicted to be in anything.