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596: CASP10 Target T0740

Closed since about 10 years ago

Advanced Overall Prediction

Summary


Created
July 11, 2012
Expires
Max points
100
Description

The fourteenth CASP10 target is another big one: 165 residues and none of the alignment programs were able to find good templates for this target. It might be the case that this protein has no homologs. We are giving you 4 different templates (in hope that one of them is correct) for now, and will provide you with some server predictions soon. More details about this CASP target are in the puzzle comments.

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Comments


beta_helix Staff Lv 1

Here is the CASP link for this target (showing the amino acid sequence):
http://predictioncenter.org/casp10/target.cgi?id=165
__________________

Here is the sequence logo predicted by the SAM server.

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Leucines at residues 106 & 141 are highly predicted to be in a helix. However, the Leucine at residue 115 is predicted to be in a sheet.

NOTE THAT THIS SECONDARY STRUCTURE PREDICTION IS OBVIOUSLY NOT 100% correct, since it is impossible to have a protein with a single sheet.
Clearly there is either another strand or there are no sheets at all!
__________________

Link to template PDBs:

http://www.pdb.org/pdb/explore/explore.do?structureId=1aep
http://www.pdb.org/pdb/explore/explore.do?structureId=2eh3
http://www.pdb.org/pdb/explore/explore.do?structureId=2gyq
http://www.pdb.org/pdb/explore/explore.do?structureId=1yvi

tamirh Lv 1

It's showing up for me in my devprev client. Is anyone else on devprev having this issue?

Have you tried restarting the client(s)? If your connection got temporarily lost it could have not downloaded the new list correctly.