Placeholder image of a protein
Icon representing a puzzle

Beginner Puzzle (<150): Docking Design

Closed since about 2 years ago

Beginner Beginner

Summary


Created
January 27, 2014
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups


  1. Avatar for Trinity Biology 100 pts. 10,365
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 83 pts. 10,333
  3. Avatar for Contenders 3. Contenders 69 pts. 10,293
  4. Avatar for Gargleblasters 4. Gargleblasters 56 pts. 10,283
  5. Avatar for Go Science 5. Go Science 45 pts. 10,225
  6. Avatar for Macromolecules@MQ 2020 6. Macromolecules@MQ 2020 36 pts. 10,209
  7. Avatar for CH4110 Fold it! 7. CH4110 Fold it! 29 pts. 10,180
  8. Avatar for Mann Fall 2020 CHEM324 8. Mann Fall 2020 CHEM324 23 pts. 10,174
  9. Avatar for KC BIO 201 FA20 9. KC BIO 201 FA20 18 pts. 10,142
  10. Avatar for Deleted group 10. Deleted group pts. 10,120

  1. Avatar for zippyc137
    1. zippyc137 Lv 1
    100 pts. 10,368
  2. Avatar for logancrane 2. logancrane Lv 1 99 pts. 10,368
  3. Avatar for alyssa_d_V2.0 3. alyssa_d_V2.0 Lv 1 98 pts. 10,365
  4. Avatar for StarlightMouse 4. StarlightMouse Lv 1 97 pts. 10,354
  5. Avatar for 3multid 5. 3multid Lv 1 96 pts. 10,346
  6. Avatar for Tifdaff 6. Tifdaff Lv 1 95 pts. 10,333
  7. Avatar for strong_base 7. strong_base Lv 1 94 pts. 10,331
  8. Avatar for 15matt95 8. 15matt95 Lv 1 93 pts. 10,328
  9. Avatar for lynx5864 9. lynx5864 Lv 1 92 pts. 10,318
  10. Avatar for Awgdawg2066 10. Awgdawg2066 Lv 1 91 pts. 10,314

Comments