Placeholder image of a protein
Icon representing a puzzle

1763: Poly-Proline Helix Design: Round 1

Closed since about 3 years ago

Intermediate Overall Design

Summary


Created
November 21, 2019
Expires
Max points
100
Description

This puzzle introduces a new secondary structure, the poly-proline helix! The starting structure is a small 38 residue protein with a frozen helix and designable residues on either end. Players should fold the starting structure to create a compact globular protein that incorporates this new type of secondary structure. Note that the backbone of the poly-proline helix has bondable oxygen atoms. If any of these oxygens are buried in the protein core, they will need to make hydrogen bonds! See the blog for more information!

Top groups


  1. Avatar for Go Science 100 pts. 8,800
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 76 pts. 8,747
  3. Avatar for Beta Folders 3. Beta Folders 56 pts. 8,736
  4. Avatar for Gargleblasters 4. Gargleblasters 41 pts. 8,729
  5. Avatar for Russian team 5. Russian team 29 pts. 8,682
  6. Avatar for Contenders 6. Contenders 20 pts. 8,678
  7. Avatar for Marvin's bunch 7. Marvin's bunch 14 pts. 8,664
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 9 pts. 8,655
  9. Avatar for FoldIt@Netherlands 9. FoldIt@Netherlands 6 pts. 8,635
  10. Avatar for Hun-Magyar Csapat 10. Hun-Magyar Csapat 4 pts. 8,581

  1. Avatar for ZeroLeak7
    1. ZeroLeak7 Lv 1
    100 pts. 8,800
  2. Avatar for Bruno Kestemont 2. Bruno Kestemont Lv 1 97 pts. 8,769
  3. Avatar for robgee 3. robgee Lv 1 93 pts. 8,744
  4. Avatar for LociOiling 4. LociOiling Lv 1 89 pts. 8,736
  5. Avatar for Deleted player 5. Deleted player pts. 8,733
  6. Avatar for Enzyme 6. Enzyme Lv 1 83 pts. 8,729
  7. Avatar for retiredmichael 7. retiredmichael Lv 1 79 pts. 8,713
  8. Avatar for phi16 8. phi16 Lv 1 76 pts. 8,708
  9. Avatar for toshiue 9. toshiue Lv 1 73 pts. 8,704
  10. Avatar for silent gene 10. silent gene Lv 1 70 pts. 8,702

Comments


Anfinsen_slept_here Lv 1

If we are designing collagen-like structures, don't we need hydroxyproline as an amino acid?

see wikipedia

and
Gorres, Kelly L.; Raines, Ronald T. (April 2010). "Prolyl 4-hydroxylase". Critical Reviews in Biochemistry and Molecular Biology. 45 (2): 106–124.

neilpg628 Staff Lv 1

Collagen happens to contain hydroxyproline (a non-canonical amino acid), but poly-proline helices (and proteins that incorporate them) do not need to contain this residue. Currently Foldit works best with the 20 encoded amino acids, so we try to design puzzles with only these residues.

bkoep Staff Lv 1

Sorry, that was an oversight! We will be sure to include the Blueprint in future puzzles!