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Puzzle 1655b: Symmetric Tetramer Design: 65 Residues

Closed since over 3 years ago

Intermediate Overall Design Symmetry


March 28, 2019
Max points

Note: This puzzle replaces Puzzle 1655, which was posted with a faulty Objective. Players may load in solutions from the original Puzzle 1655.

This symmetric design puzzle has C4 symmetry, with four symmetric chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). No more than 50% of residues may form helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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dbuske Lv 1

I have decided not to do puzzles that do not allow 360 degree movement. It makes it too difficult to do the puzzle.

bkoep Staff Lv 1

Core Existence: Monomer (max +1800)
Ensures that at least 18 residues are buried in the core of the monomer unit.

Core Existence: Complex (max +2200)
Ensures that at least 88 residues are buried in the core of the entire complex (including the interface between monomer units).

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Ideal Loops (max +500)
Penalizes any loop region that does not match one of the Building Blocks in the Blueprint tool. Use "Auto Structures" to see which regions of your protein count as loops.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.

bkoep Staff Lv 1

We haven't been able to reproduce the problem, which makes it difficult for us to figure out exactly what's going on. Can you provide some more details?

Do you mean you're having trouble rotating the camera (by clicking and dragging the background)? Or are you having trouble rotating the protein (using the move tool with purple arrows)?

Does the client crash, or do the tools stop working while Foldit continues to run?

dbuske Lv 1

No crash or stop working.
The picture does not rotate around completely.
It rotates ina wide arc. On the far back it grows
smaller and larger coming toward the player.
There is no fine control allowing full rotation.

I have a dell inspiron 1750 notebook, logitech m90 mouse,
Intel duo core

DoctorSockrates Lv 1

Actually now that you've actually described it in actual detail I think I've occasionally experienced this too, but thought nothing of it.

This has happened to me on my Windows 10 laptop, an Dell Inspiron 13 5000 series model.
Instead of the normal camera rotation system, the camera behaves very strangely; When I start dragging to rotate the camera it starts bringing the protein into the background and rotating on a weird arbitrary axis. Game function is otherwise normal; I can press the Home key or Q to reset the camera, but the camera rotation remains compromised.

I haven't gone out of my way to reproduce this, unfortunately. I've only gotten it to do this whenever I have the window sequestered to one-half of the screen (via the Windows snapping feature, WinKey+Left/Right). I have no issues on fullscreen (as far as I know), and have not had this issue on my main Windows 10 desktop. Another possible factor is that I have a touchscreen laptop, but I was using the mouse normally when this occurred.

I also apologize, I don't have any logs; reason being that when this happened I was working on something else on my laptop and had Foldit open out of boredom, so I closed it hastily afterwards and didn't pay it any mind.

bkoep Staff Lv 1

Thanks S0ckrates, this is very helpful! If you encounter this again, can you please share the solution with scientists? (And create a Feedback if you want to go the extra mile.)

We've heard other reports about proteins "walking off screen" during certain scripts. This sounds like it could be related, if the protein coordinates are being shifted too far from the origin (although this should normally be handled by resetting the camera with the Q key).