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1640: Unsolved De-novo Freestyle 147: Symmetric Dimer

Closed since over 3 years ago

Intermediate Overall Prediction Symmetry

Summary


Created
February 21, 2019
Expires
Max points
100
Description

This is a follow-up to Puzzle 1637, now with C2 symmetry. This protein was originally designed as a symmetric dimer, and we want to see if Foldit players can predict how the symmetric protein was designed to fold and bind. Players may load in solutions from Puzzle 1637. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!



Sequence:

PDLAELVVEAAKKLATLLLEATKELVKALGEKEEAKKMMTEAEKTIKEWLKELEDRMRKDPDIKKVIKMATELLATIIEMLTRILLKIQQ

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Comments


Skippysk8s Lv 1

I didn't do the first de novo, and my machine can barely work a single dimer or trimer at a time. I love symmetry puzzles, so if we could space these puzzles out I would like to work them.

Or PM me what sort of affordable computer I could buy to keep up with Loci :)

Skip

grogar7 Lv 1

Why are the results from the previous monomer puzzle loadable into this puzzle, when this one already has a set aa sequence?

frood66 Lv 1

I take my hat off 2 U - I have not seen something so appalling in all the time I have been here.

But it appears that FC have no bounds! lol

frood66 Lv 1

looks like FC need to gift about 4000 in dollars or pounds sterling - whichever the greater - to every player.

I may be banned - I cannot see vet or global - but my views remain, Take note FC - please?

grogar7 Lv 1

I get it now. The original puzzle was a design puzzle. But the loadable results are from denovo 1637 which was a monomer from that original puzzle with a set amino acid sequence. The sequence of this puzzle matches 1637. Sorry for the misunderstanding :\
Not such a mess after all, frood!