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1458: Small Monomer Design

Closed since almost 5 years ago

Intermediate Overall Design

Summary


Created
December 11, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 65-75 residues. We've softened the penalties associated with the Core Existence filter, which have typically been very steep. The starting structure has 65 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


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    1. Enzyme Lv 1
    100 pts. 10,204
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  3. Avatar for ZeroLeak7 3. ZeroLeak7 Lv 1 95 pts. 10,195
  4. Avatar for grogar7 4. grogar7 Lv 1 92 pts. 10,146
  5. Avatar for Bruno Kestemont 5. Bruno Kestemont Lv 1 89 pts. 10,119
  6. Avatar for Galaxie 6. Galaxie Lv 1 86 pts. 10,097
  7. Avatar for retiredmichael 7. retiredmichael Lv 1 84 pts. 10,096
  8. Avatar for Timo van der Laan 8. Timo van der Laan Lv 1 81 pts. 10,071
  9. Avatar for anthion 9. anthion Lv 1 79 pts. 10,069
  10. Avatar for dcrwheeler 10. dcrwheeler Lv 1 76 pts. 10,066

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 65. Players may use up to 75 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."