Placeholder image of a protein
Icon representing a puzzle

Beginner Puzzle (<150): Docking Design

Closed since almost 7 years ago

Beginner Beginner

Summary


Created
January 27, 2014
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups


  1. Avatar for Deleted group pts. 9,000
  2. Avatar for Void Crushers 2. Void Crushers 89 pts. 8,923
  3. Avatar for BCMB404-Fall2015 3. BCMB404-Fall2015 79 pts. 8,907
  4. Avatar for Androids 4. Androids 70 pts. 8,899
  5. Avatar for Deleted group 6. Deleted group pts. 8,889
  6. Avatar for FoldIt@Netherlands 7. FoldIt@Netherlands 48 pts. 8,874
  7. Avatar for foldeRNA 8. foldeRNA 42 pts. 8,869
  8. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 36 pts. 8,865
  9. Avatar for NMSU BIOL377 10. NMSU BIOL377 31 pts. 8,825

  1. Avatar for DerpDragon
    1. DerpDragon Lv 1
    100 pts. 9,084
  2. Avatar for mountain_man56 2. mountain_man56 Lv 1 100 pts. 9,047
  3. Avatar for Benny-Boyy 3. Benny-Boyy Lv 1 100 pts. 9,000
  4. Avatar for w4890888 4. w4890888 Lv 1 99 pts. 8,989
  5. Avatar for sergiodana 5. sergiodana Lv 1 99 pts. 8,955
  6. Avatar for diamond_dust 6. diamond_dust Lv 1 98 pts. 8,950
  7. Avatar for Pibeagles 7. Pibeagles Lv 1 98 pts. 8,943
  8. Avatar for teraflop 8. teraflop Lv 1 98 pts. 8,930
  9. Avatar for joublot76 9. joublot76 Lv 1 97 pts. 8,924
  10. Avatar for Neil9 10. Neil9 Lv 1 97 pts. 8,923

Comments