Placeholder image of a protein
Icon representing a puzzle

Beginner Puzzle (<150): Docking Design

Closed since about 7 years ago

Beginner Beginner

Summary


Created
January 27, 2014
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups


  1. Avatar for PunBioSummer 100 pts. 8,945
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 80 pts. 8,927
  3. Avatar for Dnice.dk 3. Dnice.dk 63 pts. 8,902
  4. Avatar for Androids 4. Androids 49 pts. 8,896
  5. Avatar for Gargleblasters 5. Gargleblasters 37 pts. 8,879
  6. Avatar for Italiani Al Lavoro 6. Italiani Al Lavoro 28 pts. 8,834
  7. Avatar for Deleted group 7. Deleted group pts. 8,832
  8. Avatar for uneRx 8. uneRx 15 pts. 8,824
  9. Avatar for CureCoin 9. CureCoin 11 pts. 8,819
  10. Avatar for FoldIt@Netherlands 10. FoldIt@Netherlands 8 pts. 8,814

  1. Avatar for Verne
    1. Verne Lv 1
    100 pts. 9,127
  2. Avatar for TJOK fan 2. TJOK fan Lv 1 100 pts. 9,085
  3. Avatar for matthenneberry 3. matthenneberry Lv 1 99 pts. 8,997
  4. Avatar for 1iD 4. 1iD Lv 1 99 pts. 8,996
  5. Avatar for Yugidude1 5. Yugidude1 Lv 1 98 pts. 8,996
  6. Avatar for joublot76 6. joublot76 Lv 1 98 pts. 8,979
  7. Avatar for bnomura19 7. bnomura19 Lv 1 97 pts. 8,945
  8. Avatar for Hongmiao Hu 8. Hongmiao Hu Lv 1 96 pts. 8,944
  9. Avatar for Sunet 9. Sunet Lv 1 96 pts. 8,939
  10. Avatar for queasyWeasel 10. queasyWeasel Lv 1 95 pts. 8,933

Comments