Placeholder image of a protein
Icon representing a puzzle

1052: 80 Residue Symmetric Trimer Design

Closed since over 7 years ago

Intermediate Overall Design Symmetry


February 13, 2015
Max points

This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders 100 pts. 16,279
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 83 pts. 16,136
  3. Avatar for L'Alliance Francophone 3. L'Alliance Francophone 68 pts. 16,078
  4. Avatar for Go Science 4. Go Science 55 pts. 15,925
  5. Avatar for Void Crushers 5. Void Crushers 44 pts. 15,851
  6. Avatar for Hun-Magyar Csapat 6. Hun-Magyar Csapat 35 pts. 15,515
  7. Avatar for Deleted group 7. Deleted group pts. 15,237
  8. Avatar for Gargleblasters 8. Gargleblasters 21 pts. 14,968
  9. Avatar for Contenders 9. Contenders 16 pts. 14,915
  10. Avatar for SETI.Germany 10. SETI.Germany 12 pts. 14,750

  1. Avatar for Deleted player pts. 16,268
  2. Avatar for Galaxie 2. Galaxie Lv 1 98 pts. 16,124
  3. Avatar for retiredmichael 3. retiredmichael Lv 1 96 pts. 16,081
  4. Avatar for Museka 4. Museka Lv 1 94 pts. 16,078
  5. Avatar for BitSpawn 5. BitSpawn Lv 1 92 pts. 16,013
  6. Avatar for pauldunn 6. pauldunn Lv 1 90 pts. 15,910
  7. Avatar for Timo van der Laan 7. Timo van der Laan Lv 1 88 pts. 15,851
  8. Avatar for MurloW 8. MurloW Lv 1 86 pts. 15,844
  9. Avatar for Bruno Kestemont 9. Bruno Kestemont Lv 1 84 pts. 15,805
  10. Avatar for gmn 10. gmn Lv 1 82 pts. 15,779


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 27% of the residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 32% of the residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.