Placeholder image of a protein
Icon representing a puzzle

1027: 80 Residue Symmetric Tetramer Design

Closed since over 7 years ago



December 18, 2014
Max points

NOTE: This puzzle has been closed and reposted as Puzzle 1027b.

This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

This puzzle will be online for two and half weeks, so take the opportunity to try several different designs!

Top groups

  1. Avatar for Anthropic Dreams 100 pts. 17,927
  2. Avatar for L'Alliance Francophone 2. L'Alliance Francophone 76 pts. 17,319
  3. Avatar for Go Science 3. Go Science 56 pts. 16,835
  4. Avatar for Beta Folders 4. Beta Folders 41 pts. 16,675
  5. Avatar for Natural Abilities 5. Natural Abilities 29 pts. 16,587
  6. Avatar for Deleted group 6. Deleted group pts. 16,268
  7. Avatar for Void Crushers 7. Void Crushers 14 pts. 15,982
  8. Avatar for Gargleblasters 8. Gargleblasters 9 pts. 15,812
  9. Avatar for Herobrine's Army 9. Herobrine's Army 6 pts. 15,025
  10. Avatar for FoldIt@Netherlands 10. FoldIt@Netherlands 4 pts. 14,375

  1. Avatar for BitSpawn
    1. BitSpawn Lv 1
    100 pts. 17,927
  2. Avatar for Museka 2. Museka Lv 1 96 pts. 17,319
  3. Avatar for Deleted player 3. Deleted player pts. 17,312
  4. Avatar for nicobul 4. nicobul Lv 1 87 pts. 17,136
  5. Avatar for christioanchauvin 5. christioanchauvin Lv 1 83 pts. 17,107
  6. Avatar for stomjoh 6. stomjoh Lv 1 79 pts. 16,965
  7. Avatar for crpainter 7. crpainter Lv 1 75 pts. 16,855
  8. Avatar for mirp 8. mirp Lv 1 71 pts. 16,835
  9. Avatar for johnmitch 9. johnmitch Lv 1 68 pts. 16,720
  10. Avatar for reefyrob 10. reefyrob Lv 1 64 pts. 16,675


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Monomer: Ensures that at least 30% of the residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 38% of the residues are buried in the core of the entire complex (including the interface between monomer units).

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets.

bkoep Staff Lv 1

Unfortunately, Foldit cannot handle the insertion and deletion of residues in symmetric puzzles. This is a feature we'd like to add, but it will require a (surprisingly) substantial amount of work.

bkoep Staff Lv 1

This looks like a bug, but I think we can avert it by reposting the puzzle.

Thanks for bringing this to our attention, Timo!

retiredmichael Lv 1

could you check the boundary condition between too many and too few in the complex, seems maybe a bit too sensitive. keep jumping from - 200 too few and - 400 too many

played with it for a bit and could not find a place between these 2 readings