Placeholder image of a protein
Icon representing a puzzle

1021: 65 Residue Monomer Design: SS Design

Closed since almost 8 years ago

Intermediate Overall Design


December 02, 2014
Max points

In this puzzle, the SS Design filter also considers the environment around each residue, in addition to secondary structure. This means that some residue types will be restricted depending on whether the position is in the core or surface of the protein. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Anthropic Dreams 100 pts. 10,124
  2. Avatar for Beta Folders 2. Beta Folders 81 pts. 10,086
  3. Avatar for Contenders 3. Contenders 65 pts. 10,035
  4. Avatar for Go Science 4. Go Science 52 pts. 10,006
  5. Avatar for Void Crushers 5. Void Crushers 41 pts. 9,995
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 32 pts. 9,967
  7. Avatar for Gargleblasters 7. Gargleblasters 24 pts. 9,956
  8. Avatar for Deleted group 8. Deleted group pts. 9,913
  9. Avatar for SETI.Germany 9. SETI.Germany 14 pts. 9,801
  10. Avatar for Hun-Magyar Csapat 10. Hun-Magyar Csapat 10 pts. 9,768

  1. Avatar for MurloW
    1. MurloW Lv 1
    100 pts. 10,121
  2. Avatar for BitSpawn 2. BitSpawn Lv 1 99 pts. 10,061
  3. Avatar for Bletchley Park 3. Bletchley Park Lv 1 97 pts. 10,035
  4. Avatar for nemo7731 4. nemo7731 Lv 1 95 pts. 10,034
  5. Avatar for retiredmichael 5. retiredmichael Lv 1 93 pts. 10,025
  6. Avatar for Bruno Kestemont 6. Bruno Kestemont Lv 1 91 pts. 10,005
  7. Avatar for Timo van der Laan 7. Timo van der Laan Lv 1 90 pts. 9,995
  8. Avatar for grogar7 8. grogar7 Lv 1 88 pts. 9,994
  9. Avatar for johnmitch 9. johnmitch Lv 1 86 pts. 9,969
  10. Avatar for Museka 10. Museka Lv 1 84 pts. 9,967


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.

spmm Lv 1

there have been a lot design puzzles but there don't seem to have been any successful ones.

spmm Lv 1

it is actually facing internally towards another hydro and is loosing points. Not 'on the surface' at all.

bkoep Staff Lv 1

We realize it's been a while since we've given any substantial feedback on Foldit designs! Alpha/beta proteins are very tricky to design, but we've been seeing steady incremental progress. I'd like to make a blog post soon about the types of challenges we perceive in the current design environment.

bkoep Staff Lv 1

This looks like a slip up in the filter setup for this specific puzzle. Should be fixed in future puzzles.

Thanks for the feedback!