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Recipe: Mutate Sphere 1.1.0 TNT
Created by Rav3n_pl 68 1814
Your rating: None Average: 5 (4 votes)
Used 821 times with an average impact of -6 points.


Name: Mutate Sphere 1.1.0 TNT
ID: 8927
Created on: Sat, 08/21/2010 - 11:03
Updated on: Sun, 08/22/2010 - 23:56

Searhcing mutable sgmnt then mutate sphere of sgmnts.

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Joined: 06/17/2010

It works like that:
- walk from point to point
- check for mutable segment
- if found select sphere
- mutate sphere until any change (max 3 times, using do_mutate())
- select larger sphere
- shake/wiggle side chains
- if score drops reload
- next

By default it walks entire protein! In TNT it may take LOOOONG time on slower (like mine:P) PCs!

Joined: 06/17/2010

- repaired bug in mutable detection
- added parameters for small and large sphere (small for mutate, large for shakeout)
- unmutable segments are shaked in large sphere
- added parameter to go backward (from end)

Sometimes (in well shaked proteine) it gets less per 0.001 pts and tells "gain: 0"

Try to run after reset and aligned TNT :)

Joined: 08/11/2010
Groups: None
Please, put the script on

Please, put the script on Strongly buggy downloading recipes.

Joined: 09/18/2009
Groups: SETI.Germany

Interesting strategy.

I put it on pastebin:

Joined: 08/09/2010
Groups: foldeRNA

I've had this idea for so long, but not the programing skill to write it

Joined: 08/09/2010
Groups: foldeRNA
My idea was more along the

My idea was more along the lines of going down the line mutating all of the mutables one AA at a time, and then doing a sphere of mutations [perhaps with do_mutate() ] around the directed mutation.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons