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Puzzle
Expired: 03/31/22 23:00:00
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 13,292
Categories:
This sandbox puzzle features a monomer protein design by Bletchley Park from Puzzle 2106. This design forms an NTF2 fold, with an open pocket that could be repurposed to bind a small molecule.
Puzzle
Expired: 03/03/22 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 11,146
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is involved in the process of exocytosis, transporting proteins to the cell membrane or extracellular areas. The protein is modeled here in reduced form, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 03/04/22 23:00:00
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 28,662
Categories: Electron Density, Overall, Prediction
The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. In addition to the protein chain, puzzle includes a glutathione ligand that is fixed in place.
Puzzle
Expired: 03/02/22 23:00:00
2 comments
Top Group: Contenders
Top Player: dcrwheeler
Top Score: 22,316
Categories: Design, Overall, Symmetry
Design a symmetric protein tetramer, with 4 identical chains of 80 residues each! This puzzle enables AlphaFold predictions for the monomer subunit of your design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your monomer subunit only (i.e. in the unbound state, in the absence of other symmetric copies). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the monomer subunit interacts with symmetric copies.
Puzzle
Expired: 02/25/22 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 13,832
Categories: Design, Overall
Note: This puzzle replaces Puzzle 2111 which mistakenly allowed parts of the target chain to move. Players may not load work from the original Puzzle 2111.
Puzzle
Expired: 02/25/22 23:00:00
4 comments
Top Group: Anthropic Dreams
Top Player: robgee
Top Score: 12,846
Categories:
Note: This puzzle was closed early due to an error that allowed parts of the target chain to move. This puzzle has been reposted as Puzzle 2111b.
Puzzle
Expired: 02/24/22 18:00:00
1 comment
Top Group: Marvin's bunch
Top Player: fpc
Top Score: 11,277
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin is produced in the intestines of the African black mamba. The protein contains ten cysteines that oxidize to form five disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 02/23/22 23:00:00
11 comments
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 19,682
Categories: Design, Overall, Symmetry
Design a symmetric protein tetramer, with 4 identical chains of 60 residues each! This puzzle enables AlphaFold predictions for the monomer subunit of your design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your monomer subunit only (i.e. in the unbound state, in the absence of other symmetric copies). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the monomer subunit interacts with symmetric copies.
Puzzle
Expired: 02/18/22 23:00:00
1 comment
Top Group: Marvin's bunch
Top Player: jausmh
Top Score: 20,121
Categories: Electron Density, Overall, Prediction
The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. In addition to the protein chain, puzzle includes three sulfate ions that are fixed in place.
Puzzle
Expired: 02/17/22 18:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 10,962
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is an allergen produced by the white birch tree. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons