Puzzles Feed

Closed

Puzzle
Expired: 09/19/18 18:00:00
17 comments
Top Group: Go Science
Top Player: Hollinas
Top Score: 20,781
Categories: Small Molecule Design

Due to reports of persistent crashing and issues with loading/saving solutions, we've changed this puzzle to be worth zero points. We're leaving it open, though, for those people who still want to play around with it.

Puzzle
Expired: 09/17/18 23:00:00
5 comments
Top Group: Beta Folders
Top Player: matosfran
Top Score: 18,560
Categories: Electron Density, Overall, Prediction
This is a repost of Puzzle 1554, now with electron density! This protein is part of a large protein complex with multiple subunits, which has recently been the target of some cryo-electron microscopy (cryo-EM) experiments. Load in your Puzzle 1554 solutions and see if you can improve them to fit the density! We are giving you the same 5 server predictions as starting points. NOTE: If you did not manually save a solution in Puzzle 1554, you can go back to 1554, manually save it, and the solution should appear in your manual saves for this puzzle.
Puzzle
Expired: 09/12/18 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,432
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This pheromone protein is secreted by the protist E. raikovi to initiate conjugation, the exchange of genetic material between two cells. This protein contains ten cysteine residues that oxidize to form five disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/10/18 23:00:00
8 comments
Top Group: Go Science
Top Player: isaksson
Top Score: 22,833
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C3 symmetry, with three symmetric chains. The H-bond Network Filter encourages players to bury satisfied H-bond networks at the interface between the three chains. We've doubled the H-bond network bonus, but we'd like players to focus on building networks deep in the core of the protein complex. There a couple other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 09/13/18 23:00:00
9 comments
Top Group: Beta Folders
Top Player: matosfran
Top Score: 12,800
Categories: Design, Overall
This the Phase One design puzzle for the Protein Design Partition Tournament! Players have two weeks to craft their best protein design, which will have to defend itself in Phase Two of the tournament. For players who do not wish to participate in the tournament, this puzzle will also behave like a normal Foldit puzzle, and points will be awarded to top-ranking players and teams as usual. Players may use 70-100 residues, at a cost of 32 points per residue; and designs with more than 10% helices will be penalized 10 points per extra residue in a helix.
Puzzle
Expired: 09/05/18 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,371
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein binds copper ions so that they may be transported safely to the cell compartments and enzymes that require them. The protein is modeled here in the reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/03/18 23:00:00
6 comments
Top Group: Anthropic Dreams
Top Player: fiendish_ghoul
Top Score: 18,773
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C2 symmetry, with two symmetric chains. The H-bond Network Bonus encourages players to bury satisfied H-bond networks at the interface between the two chains. We've doubled the H-bond network bonus, but we'd like players to focus on building networks deep in the core of the protein complex. There are a couple other bonuses in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 08/30/18 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 12,183
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 65-75 residues. The starting structure has 65 residues, but more can be added at a cost of 32 points per residue. We've recently amended the old system of Conditions, or Filters. These have been rebranded as Objectives, and are reformulated so that they typically increase the base Foldit score (although it is still possible to receive a penalty from an Objective, in some cases). Ultimately, the function of each Objective is the same as it always has been (e.g. adding a residue still subtracts 32 points from the Residue Count objective), but we hope that the Objectives will be more encouraging than the old Filters—especially for new players who are still getting the hang of things. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 08/29/18 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 9,868
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This storage protein is used to stockpile amino acids for future use, and is found at high concentration in the seeds of certain plants. This particular protein was used by scientists in 2011 to collect the highest-resolution crystal structure to date. This protein contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 08/27/18 23:00:00
2 comments
Top Group: Go Science
Top Player: NinjaGreg
Top Score: 14,300
Categories: Design, Overall
This puzzle is a little different from other H-bond network design puzzles in Foldit. This protein is another dimer (i.e. two chains fold up and bind each other) that was designed in the Baker Lab. The original design has three different H-bond networks that span the interface between the two chains, but we've mutated the network residues to alanine. In order to solve this puzzle, Foldit players will have to mutate the alanine residues back into residues that can form satisfied H-bond networks. The protein backbone is fixed in this puzzle, and only the alanine residues can be mutated. We want to know how well Foldit players are able to find networks using the tools currently in Foldit.
Get Started: Download
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons