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Puzzle
Expired: 04/17/18 23:00:00
3 comments
Top Group: Gargleblasters
Top Player: dcrwheeler
Top Score: 33,201
Categories:
Design a protein that could be used as a vaccine for malaria! Malaria is a deadly disease caused by the parasite P. falciparum, which makes circumsporozoite protein (CSP) to grow and infect human cells. The human immune system can combat malaria by producing antibodies that recognize CSP on the surface of the parasite. However, the immune system is not always successful, in part because CSP is a highly flexible protein that can exchange between different structures. It was recently discovered that human antibodies can protect against malarial infection if they bind to a CSP loop in a particular "vulnerable" structure; but antibodies targeting alternative structures of CSP do not halt infection. If we can design a protein that contains the CSP loop in the vulnerable conformation, the protein could be used as a vaccine to prepare the immune system against malaria (by raising antibodies that bind the vulnerable CSP structure)!
Puzzle
Expired: 04/16/18 18:00:00
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 10,156
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small, intracellular domain binds to the CD2 T cell receptor (TCR), and plays a critical role in T cell activation during the immune response. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 04/18/18 23:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 13,845
Categories: Design, Overall
The Siegel Lab has identified a new protein scaffold that could potentially serve to degrade aflatoxin! This puzzle uses a different starting structure than Rounds 1-6 of the Aflatoxin Challenge, but the goal is the same: Redesign the active site to bind aflatoxin! Note that loop residues 62-69 in the starting structure clash with the aflatoxin molecule. Although residue insertions are not allowed in this puzzle, players may remove residues from this loop. Parts of the scaffold protein have been trimmed to reduce the size of the puzzle, and we've upweighted ligand interactions by a factor of five. We'd like to see if Foldit players can design proteins that make more interactions with the ligand! See the blog for more details.
Puzzle
Expired: 04/10/18 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 11,942
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 04/09/18 23:00:00
3 comments
Top Group: Go Science
Top Player: toshiue
Top Score: 6,077
Categories: Overall
This is a ligand docking puzzle. Instead of changing the protein, we'd like you to focus on finding the best position and interactions for the ligand. (The residue in the middle of the alpha helices, currently making a number of clashes.)

Puzzle
Expired: 04/03/18 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 11,422
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 04/02/18 23:00:00
6 comments
Top Group: Beta Folders
Top Player: RockOn
Top Score: 10,390
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. These are the two chains of a bio-engineered variant of human insulin, which contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 04/04/18 23:00:00
2 comments
Top Group: Beta Folders
Top Player: bertro
Top Score: 13,644
Categories: Overall, Prediction
The aflatoxin puzzles are back! This puzzle is very similar to Puzzle 1455: Aflatoxin Challenge: Round 4, but parts of the scaffold protein have been trimmed to reduce the size of the puzzle, and we've upweighted ligand interactions by a factor of five. We'd like to see if Foldit players can design proteins that make more interactions with the ligand! See the blog for more details. Unfortunately, due to the scaffold trimming and the recent Foldit update, players will not be able to load solutions from Puzzle 1455.
Puzzle
Expired: 03/27/18 23:00:00
7 comments
Top Group: Gargleblasters
Top Player: ManVsYard
Top Score: 16,021
Categories: Design, Overall, Symmetry
Note: This puzzle replaces Puzzle 1499 which was posted with a problematic filter. Players may load in solutions from Puzzle 1499.
Puzzle
Expired: 03/27/18 23:00:00
1 comment
Top Group: Go Science
Top Player: rabamino12358
Top Score: 1,804
Categories:
Note: This puzzle replaces Puzzle 1499 which was posted with a problematic filter. Players may load in solutions from Puzzle 1499.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons