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Puzzle
Expired: 11/05/20 23:00:00
5 comments
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 17,539
Categories: Design, Overall
Design a binder for the viral spike of MERS-CoV! This puzzle is similar to Puzzle 1907, but now includes special Foldit Metrics for the DDG, SASA, and SC of your solution. These Metrics are slow to compute and run in the background, so gameplay may be different from regular puzzles. Each Metric has a target, players will receive a 1000 pt bonus for meeting each target. See the blog for more info about Foldit Metrics.
Puzzle
Expired: 11/04/20 23:00:00
1 comment
Top Group: Contenders
Top Player: CharlieFortsCon...
Top Score: 21,650
Categories: Design, Overall, Symmetry
Design a symmetric protein tetramer, with 4 identical chains that assemble together! The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 10/30/20 18:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 9,860
Categories: Overall, Prediction
Refold the loops in this Aflatoxin Challenge design! In the most recent lab tests the Siegel Lab identified three well-behaved designs that show activity against aflatoxin. We want to know how these designs fold in the absence of aflatoxin. This puzzle features a protein designed by LociOiling in Puzzle 1739, but the starting structure has been partially unfolded. Help us predict the structure of this design by folding the redesigned loops!
Puzzle
Expired: 10/29/20 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: Formula350
Top Score: 14,229
Categories: Design, Overall
Design a binder for the viral spike of MERS-CoV! MERS is a respiratory disease similar to COVID-19, and is caused by a related coronavirus. There have been several MERS outbreaks since 2012, but there is still no treatment has been developed for the disease. The MERS-CoV virus is coated with a spike protein that recognizes the human protein DPP4, which is found on the surface of lung cells. A protein that binds to the MERS-CoV spike could be used as a drug to block DPP4 recognition and slow viral infection.
Puzzle
Expired: 10/29/20 23:00:00
9 comments
Top Group: Go Science
Top Player: weck1503
Top Score: 594,425
Categories:
This non-competitive sandbox puzzle features a new kind of Objective that we're calling Metrics. Metrics are slow to compute, so they are calculated in the background while you're folding your protein. That means that sometimes your score will be greyed out while the metrics are computing, but if you wait just a second then they will finish and your score will regain color. See the blog for more info about Metrics in Foldit. This is a multi-start puzzle with binders for the Coronavirus spike. You can start the puzzle with (1) a fragment of the natural ACE2 receptor, (2) the designed binder LCB1, or (3) an extended chain so you can design your own. Cycle through the different starting structures by resetting the puzzle. The puzzle Objectives include three Metrics (DDG, SASA, SC), so that you can practice designing protein binders using these binder metrics. This puzzle is non-competitive and will award no points.
Puzzle
Expired: 10/28/20 23:00:00
1 comment
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 24,500
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle includes a Secondary Structure Objective, so no more than 50% of your design can form helices. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 10/23/20 18:00:00
Top Group: L'Alliance Francophone
Top Player: nicobul
Top Score: 9,720
Categories: Overall, Prediction
Refold the loops in this Aflatoxin Challenge design! In the most recent lab tests the Siegel Lab identified three well-behaved designs that show activity against aflatoxin. We want to know how these designs fold in the absence of aflatoxin. This puzzle features a protein designed by Phyx in Puzzle 1739, but the starting structure has been partially unfolded. Help us predict the structure of this design by folding the redesigned loops!
Puzzle
Expired: 10/22/20 23:00:00
1 comment
Top Group: Go Science
Top Player: ichwilldiesennamen
Top Score: 15,142
Categories: Design, Overall
Design a binder against coronavirus! This puzzle includes optional Objectives for the binder metrics. The DDG, SASA, and SC Objectives will not award any bonuses and should not affect recipes, but you can run these Objectives to check the binder metrics of your design. We've also adjusted the BUNS objective to ignore many of the "unsolvable" BUNS in the frozen target. Remember, if your designed protein creates Buried Unsats, then it will be less likely to fold and bind to the coronavirus target. (Note that this target protein includes 3 buried unsats that players may be unable to fix.) See the blog for more details about buried unsats, and for helpful tips to make a successful protein binder! Players may not load solutions from previous puzzles.
Puzzle
Expired: 10/21/20 23:00:00
9 comments
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 21,926
Categories: Design, Overall
Note: This puzzle replaces Puzzle 1903, which had some errors in the puzzle setup. Players may not load solutions from Puzzle 1903.
Puzzle
Expired: 10/21/20 23:00:00
2 comments
Top Group: Gargleblasters
Top Player: Enzyme
Top Score: 18,284
Categories:
Note: This puzzle was closed early due to problems in the puzzle setup. A corrected version has been posted as Puzzle 1903b.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons