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Puzzle
Expired: 01/01/21 23:00:00
5 comments
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 33,152
Categories: Design, Overall
Design an interface between two protein chains! This puzzle is much like Puzzle 1929, with a suite of Core Existence Objectives to ensure that both chains have a substantial core. The starting structure includes two helical hairpins that are frozen in place and separated from one another. We want to build on these hairpins to create a binding interface between the two protein chains. However, the starting position of the hairpins is important, so the locked hairpins are held in place by strong constraints. The only way to make the two chains bind will be to fold up a brand new interface between them.
Puzzle
Expired: 12/31/20 18:00:00
1 comment
Top Group: Go Science
Top Player: mirp
Top Score: 11,640
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This human protein helps to regulate the reduction potential of the cell, and should be modeled here in reduced form (without disulfides bonds). We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with problems that are still scientifically relevant.
Puzzle
Expired: 12/30/20 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: Mike Lewis
Top Score: 12,736
Categories: Design, Overall
This is the eighth puzzle in the designable linker series! We are providing parts of two of the best-known designed binders to the SARS-CoV-2 spike, and are challenging players to link them together with a rigid linker! The two helical bundles are the parts of the two binders. They are currently connected with a flexible alanine linker that needs to be redesigned.
Puzzle
Expired: 01/02/21 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 15,421
Categories:
Design your best-looking snowflake! Take a break with this non-competitive, non-scientific puzzle and fold up a protein chain with 6-fold symmetry. This puzzle is not worth any points, and no solutions will be analyzed for scientific merit. But the Foldit team will sort through any solutions that you share with scientists, and we'll pick out our favorite snowflake designs to be highlighted in the next newsletter!
Puzzle
Expired: 12/25/20 23:00:00
6 comments
Top Group: Go Science
Top Player: toshiue
Top Score: 21,072
Categories: Design, Overall, Symmetry
Design a symmetric protein tetramer, with 4 identical chains that assemble together! The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 12/24/20 18:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 11,250
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small protein is a component of the major histocompatibility complex (MHC) which is essential to a functioning immune system. The starting structure is a Rosetta model. This protein contains two cysteine residues that are oxidized to form one disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with problems that are still scientifically relevant.
Puzzle
Expired: 12/23/20 23:00:00
4 comments
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 12,996
Categories: Design, Overall
This is the seventh puzzle in the designable linker series! We are providing parts of two of the best-known designed binders to the SARS-CoV-2 spike, and are challenging players to link them together with a rigid linker! The two helical bundles are the parts of the two binders. They are currently connected with a flexible alanine linker that needs to be redesigned.
Puzzle
Expired: 12/18/20 23:00:00
2 comments
Top Group: Go Science
Top Player: toshiue
Top Score: 23,183
Categories: Design, Overall
Design an interface between two protein chains! This is a followup puzzle to Puzzle 1903b, with a greater allowance of insertable residues and a stricter Core Existence Objective. The starting structure includes two helical hairpins that are frozen in place and separated from one another. We want to build on these hairpins to create a binding interface between the two protein chains. However, the starting position of the hairpins is important, so the locked hairpins are held in place by strong constraints. The only way to make the two chains bind will be to fold up a brand new interface between them.
Puzzle
Expired: 12/17/20 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 12,396
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is part of a signaling pathway that regulates sporulation in B. subtilis; the starting structure is a model produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 12/16/20 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: Enzyme
Top Score: 10,279
Categories: Design, Overall
This is the sixth puzzle in the designable linker series! We are providing parts of two of the best-known designed binders to the SARS-CoV-2 spike, and are challenging players to link them together with a rigid linker! The two helical bundles are the parts of the two binders. They are currently connected with a flexible alanine linker that needs to be redesigned. Note that this puzzle has as different starting structure than previous puzzles and is about linking a different pair of the same binders.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons