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Puzzle
Expired: 04/26/18 23:00:00
Top Group: Biochemistry 315 2018
Top Player: parsnip
Top Score: 12,312
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expired: 03/21/18 23:00:00
6 comments
Top Group: Void Crushers
Top Player: Madde
Top Score: 13,263
Categories: Design, Overall
The aflatoxin puzzles are back! This puzzle is very similar to Puzzle 1440: Aflatoxin Challenge: Round 1, but parts of the scaffold protein have been trimmed to reduce the size of the puzzle, and we've upweighted ligand interactions by a factor of five. We'd like to see if Foldit players can design proteins that make more interactions with the ligand! See the blog for more details. Unfortunately, due to the scaffold trimming and the recent Foldit update, players will not be able to load solutions from Puzzle 1440.
Puzzle
Expired: 03/20/18 23:00:00
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 11,470
Categories: Design, Overall
This is another "primitive" style design puzzle, meaning that we've disabled most of the filters normally used for Foldit protein design. This puzzle debuts a brand new, state-of-the-art score function that has shown improved accuracy in some protein modeling benchmarks. We're curious to see if this score function also improves design accuracy in Foldit. What's the best scoring design you can come up with using the new score function?
Puzzle
Expired: 03/19/18 18:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,706
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This scorpion toxin binds to voltage-gated ion channels in insects, resulting in full-body paralysis. The protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 03/13/18 18:00:00
Top Group: Go Science
Top Player: toshiue
Top Score: 9,203
Categories: Overall, Prediction
This is a puzzle we first ran in August of 2016; however, an error in our data handling system meant that the player solutions from that puzzle were lost before we could back them up. The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets! If players still have solutions from the original Puzzle 1271, they may load them into this puzzle.
Puzzle
Expired: 03/13/18 18:00:00
Top Group: Go Science
Top Player: Hollinas
Top Score: 9,850
Categories: Design, Overall
This is another "primitive" style puzzle, in which we've disabled most of the filters normally used for Foldit protein design. The only filter in this puzzle is the CoreExists filter. Foldit has changed a great deal since we ran the first Foldit design puzzle, back in August of 2009, and the results of recent design puzzles have shown that Foldit players are now perfectly capable of designing well-folded, stable proteins. We'd like to write up a paper about these results, and it will be important to have a clear picture of what happens without those special tools and filters now used for protein design. For this puzzle, we're asking Foldit players to forget everything you've learned about protein design! This puzzle uses only a basic Rosetta scoring function, and we do not expect top-scoring designs to be realistic. But we're very curious whether Foldit players will find the same solutions as back in 2009. What is the best-scoring structure you can fold, with only the CoreExists filter?
Puzzle
Expired: 04/19/18 23:00:00
Top Group: Italiani Al Lavoro
Top Player: ourtown
Top Score: 10,348
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expired: 03/13/18 18:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 9,112
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This kinase protein is part of a human signaling pathway that controls cell growth. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 03/09/18 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: Enzyme
Top Score: 10,617
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 03/08/18 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 9,537
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons