Puzzles Feed

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Puzzle
Expired: 04/08/19 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 9,767
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small protein participates in electron transfer reactions in the cell. The protein is modeled here in reduced form, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 04/04/19 23:00:00
8 comments
Top Group: Contenders
Top Player: johnmitch
Top Score: 20,609
Categories: Design, Overall, Symmetry
Note: This puzzle replaces Puzzle 1655, which was posted with a faulty Objective. Players may load in solutions from the original Puzzle 1655.
Puzzle
Expired: 04/04/19 23:00:00
1 comment
Top Group: Russian team
Top Player: cbwest
Top Score: 17,676
Categories:
Note: This puzzle was closed early due to a faulty Objective, and reposted as Puzzle 1655b. Players may load their current work into the reposted puzzle.
Puzzle
Expired: 04/01/19 18:00:00
2 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 11,132
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is involved in the process of exocytosis, transporting proteins to the cell membrane or extracellular areas. The protein is modeled here in reduced form, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 04/02/19 23:00:00
4 comments
Top Group: Void Crushers
Top Player: Mike Cassidy
Top Score: 9,793
Categories: Overall
THIS IS A MULTISTART PUZZLE - Click "RESET PUZZLE" to cycle through each of six starting structures.

Puzzle
Expired: 03/28/19 23:00:00
5 comments
Top Group: Anthropic Dreams
Top Player: fiendish_ghoul
Top Score: 15,654
Categories: Overall, Prediction, Symmetry
This is a follow-up to Puzzle 1649: De-novo Freestyle 149, now with C2 symmetry. This protein was originally designed by a Foldit player as a symmetric dimer. In Puzzle 1649, we challenged the Foldit community to try and predict how the design might fold as a single, monomeric chain. Now we want to see if Foldit players can predict how the original protein was designed to fold and bind to itself with C2 symmetry. Players may load in solutions from Puzzle 1649. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 03/27/19 18:00:00
4 comments
Top Group: Beta Folders
Top Player: smilingone
Top Score: 11,251
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin is produced in the intestines of the African black mamba. The protein contains ten cysteines that oxidize to form five disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 03/26/19 23:00:00
8 comments
Top Group: Go Science
Top Player: johnmitch
Top Score: 169,992
Categories: Design, Overall
Note: Due to some recent server problems, the puzzle expiration will be extended 24 hours. The puzzle will close on March 26 at 23:00 GMT.
Puzzle
Expired: 03/25/19 23:00:00
4 comments
Top Group: Beta Folders
Top Player: johnmitch
Top Score: 0
Categories:
Note: This puzzle was closed early due to a miscalibrated score function. The puzzle has been reposted as Puzzle 1650b.
Puzzle
Expired: 03/21/19 23:00:00
Top Group: Anthropic Dreams
Top Player: fiendish_ghoul
Top Score: 10,937
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons