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Puzzle
Expired: 04/09/18 23:00:00
3 comments
Top Group: Go Science
Top Player: toshiue
Top Score: 6,077
Categories: Overall
This is a ligand docking puzzle. Instead of changing the protein, we'd like you to focus on finding the best position and interactions for the ligand. (The residue in the middle of the alpha helices, currently making a number of clashes.)

Puzzle
Expired: 05/10/18 23:00:00
Top Group: Hun-Magyar Csapat
Top Player: Ribo-soma
Top Score: 9,191
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expired: 04/03/18 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 11,422
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 04/02/18 23:00:00
6 comments
Top Group: Beta Folders
Top Player: RockOn
Top Score: 10,390
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. These are the two chains of a bio-engineered variant of human insulin, which contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 04/04/18 23:00:00
2 comments
Top Group: Beta Folders
Top Player: bertro
Top Score: 13,644
Categories: Overall, Prediction
The aflatoxin puzzles are back! This puzzle is very similar to Puzzle 1455: Aflatoxin Challenge: Round 4, but parts of the scaffold protein have been trimmed to reduce the size of the puzzle, and we've upweighted ligand interactions by a factor of five. We'd like to see if Foldit players can design proteins that make more interactions with the ligand! See the blog for more details. Unfortunately, due to the scaffold trimming and the recent Foldit update, players will not be able to load solutions from Puzzle 1455.
Puzzle
Expired: 03/27/18 23:00:00
7 comments
Top Group: Gargleblasters
Top Player: ManVsYard
Top Score: 16,021
Categories: Design, Overall, Symmetry
Note: This puzzle replaces Puzzle 1499 which was posted with a problematic filter. Players may load in solutions from Puzzle 1499.
Puzzle
Expired: 05/03/18 23:00:00
1 comment
Top Group: Hun-Magyar Csapat
Top Player: Ribo-soma
Top Score: 9,310
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Puzzle
Expired: 03/27/18 23:00:00
1 comment
Top Group: Go Science
Top Player: rabamino12358
Top Score: 1,804
Categories:
Note: This puzzle replaces Puzzle 1499 which was posted with a problematic filter. Players may load in solutions from Puzzle 1499.
Puzzle
Expired: 03/27/18 23:00:00
15 comments
Top Group: Go Science
Top Player: caglar
Top Score: 13,956
Categories:
This symmetric design puzzle has C2 symmetry, with two symmetric chains. The H-bond Network Filter encourages players to bury satisfied H-bond networks at the interface between the two chains. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 03/26/18 18:00:00
Top Group: Gargleblasters
Top Player: eusair
Top Score: 10,711
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This scorpion toxin is similar to the one from Puzzle 55, and binds to voltage-gated ion channels of insects. The protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons