Closed

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

This is a throwback puzzle to the early days of Foldit. This protein, which inhibits muscle contraction in the absence of calcium ions, changes conformation in the presence of calcium to allow muscle contraction. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

This is a repost of Puzzle 1572, which was unable to load solutions from the previous Puzzle 1554. Players may now load solutions from Puzzle 1554, as well as any work in the original Puzzle 1572. NOTE: If you did not manually save a solution in 1554 or 1572, you can go back to either puzzle, manually save it, and the solution should appear in your manual saves for this puzzle.

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

This is a throwback puzzle to the early days of Foldit. This toxin is found in green mamba venom, and blocks the flow of calcium ions that normally depolarize the muscle cell to induce muscle contraction. This protein contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by silent gene from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.

Note: This puzzle was closed early, because challengers found decoy states with lower energy than the initial design. Try one of the other partition puzzles!

This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by fiendish_ghoul from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.

This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by actiasluna from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.

This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by robgee from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.