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Puzzle
Expired: 04/17/20 23:00:00
15 comments
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 13,163
Categories: Design, Overall
Design an anti-inflammatory protein for COVID-19! Many COVID-19 complications are caused indirectly by the virus, and result from a severe over-stimulation of the human immune system. This kind of immune over-stimulation is commonly called a "cytokine storm." During a viral infection, immune cells normally release signaling proteins called cytokines, which inform the rest of the immune system about the infection and trigger inflammation. The inflammation is supposed to help the immune system fight off the infection, but too much inflammation can result in sepsis and organ failure.
Puzzle
Expired: 04/16/20 23:00:00
17 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,825
Categories: Overall, Prediction
This is a follow-up to Puzzle 1820, but this time we are providing you with a starting model. Players may load in previous work from Puzzle 1820. This protein is encoded in the viral genome of SARS-CoV-2, but the protein's structure is still unknown. If we knew how this protein folds, we might be able to figure out its exact function. Refold this starting model to find higher-scoring solutions, which will tell us how this protein is most likely to fold!
Puzzle
Expired: 04/15/20 18:00:00
4 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 9,904
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is found in the nucleus of stem cells in mice, and is important for maintaining the pluripotency of the stem cell. The protein is modeled here as in a reduced environment, so no disulfide bonds are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 04/10/20 23:00:00
7 comments
Top Group: Gargleblasters
Top Player: Formula350
Top Score: 16,302
Categories: Design, Overall
Design a binder against coronavirus! We're challenging players to design an antiviral protein that could bind to the 2019 coronavirus spike protein and disrupt viral infection. The starting structure is a solution designed by Steven Pletsch in our previous Round 3 puzzle. This solution makes an excellent interface with the target, but we're concerned that the binder may not fold properly, especially the loops connecting the three helices. We're asking Foldit players to try and improve this design so that it folds up correctly and can bind to the target! Players also have freedom to redesign an entirely new solution from scratch.
Puzzle
Expired: 04/09/20 23:00:00
12 comments
Top Group: Anthropic Dreams
Top Player: grogar7
Top Score: 10,812
Categories: Overall, Prediction
Fold this coronavirus protein! This protein is encoded in the viral genome of SARS-CoV-2, in a region called ORF8, but the protein's structure is still unknown. Evidence suggests this protein triggers a stress signal in the infected cell. If we knew how this protein folds, we might be able to figure out its exact function. The puzzle's starting structure shows SS predictions from PSIPRED, and hints which parts of the protein might fold into helices or sheets. Refold this protein to find high-scoring solutions, which will tell us how this protein is most likely to fold!
Puzzle
Expired: 04/08/20 18:00:00
4 comments
Top Group: Herobrine's Army
Top Player: HerobrinesArmy
Top Score: 10,577
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This is a portion of a troponin protein found in the skeletal muscle of turkeys. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 04/03/20 23:00:00
4 comments
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 16,420
Categories: Design, Overall
Design a binder against coronavirus! We're challenging players to design an antiviral protein that could bind to the 2019 coronavirus spike protein and disrupt viral infection. The starting structure is a solution designed by spvincent in our previous Round 2 puzzle. This solution makes an excellent interface with the target, but we're concerned that the binder may not fold properly. Our predictions suggest that the two sheets in this solution will not fold up as designed. We're asking Foldit players to try and improve this design so that it folds up correctly and can bind to the target! Players also have freedom to redesign an entirely new solution from scratch.
Puzzle
Expired: 04/02/20 23:00:00
14 comments
Top Group: Hold My Beer
Top Player: AntiVaccine
Top Score: 9,477
Categories: Overall, Prediction
Refold this coronavirus protein! This protein is encoded in the viral genome of SARS-CoV-2, in a region called ORF6, but the protein's structure is still unknown. Evidence suggests this protein inhibits the natural immune response, helping the virus survive and replicate. If we knew how this protein folds, we might be able to figure out exactly how it inhibits the immune system. The puzzle's starting structure shows SS predictions from PSIPRED, and hints which parts of the protein might fold into helices or sheets. Refold this protein to find high-scoring solutions, which will tell us how this protein is most likely to fold!
Puzzle
Expired: 04/01/20 18:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 9,246
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This is a trypsin inhibitor in pumpkins. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant. Players will NOT be able to load in any previous solutions for these puzzles.
Puzzle
Expired: 03/27/20 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 23,094
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains that assemble together! The H-bond Network Objective encourages players to bury satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons