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Puzzle
Expired: 12/23/20 23:00:00
4 comments
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 12,996
Categories: Design, Overall
This is the seventh puzzle in the designable linker series! We are providing parts of two of the best-known designed binders to the SARS-CoV-2 spike, and are challenging players to link them together with a rigid linker! The two helical bundles are the parts of the two binders. They are currently connected with a flexible alanine linker that needs to be redesigned.
Puzzle
Expired: 12/18/20 23:00:00
2 comments
Top Group: Go Science
Top Player: toshiue
Top Score: 23,183
Categories: Design, Overall
Design an interface between two protein chains! This is a followup puzzle to Puzzle 1903b, with a greater allowance of insertable residues and a stricter Core Existence Objective. The starting structure includes two helical hairpins that are frozen in place and separated from one another. We want to build on these hairpins to create a binding interface between the two protein chains. However, the starting position of the hairpins is important, so the locked hairpins are held in place by strong constraints. The only way to make the two chains bind will be to fold up a brand new interface between them.
Puzzle
Expired: 12/17/20 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 12,396
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is part of a signaling pathway that regulates sporulation in B. subtilis; the starting structure is a model produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 12/16/20 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: Enzyme
Top Score: 10,279
Categories: Design, Overall
This is the sixth puzzle in the designable linker series! We are providing parts of two of the best-known designed binders to the SARS-CoV-2 spike, and are challenging players to link them together with a rigid linker! The two helical bundles are the parts of the two binders. They are currently connected with a flexible alanine linker that needs to be redesigned. Note that this puzzle has as different starting structure than previous puzzles and is about linking a different pair of the same binders.
Puzzle
Expired: 12/11/20 23:00:00
2 comments
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 14,977
Categories: Design, Overall
Design a binder for the viral spike of MERS-CoV! We really liked some of the top-scoring solutions coming out of the previous Round 6 puzzle, and this puzzle is set up the same way. In this puzzle, the Metrics have a ramped bonus; as you improve DDG, SASA, and SC, you will get an increasing bonus until you reach the threshold of DDG < -40, SASA > 1500, and SC > 0.6, and then the bonus will be capped. Remember that Metrics are slow to compute and run in the background, so gameplay may be different from regular puzzles. See the blog for more info about Foldit Metrics.
Puzzle
Expired: 12/10/20 18:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Aubade01
Top Score: 11,621
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is a phosphatase that participates in several metabolic pathways; the starting structure is a model produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with problems that are scientifically relevant.
Puzzle
Expired: 12/09/20 23:00:00
7 comments
Top Group: Gargleblasters
Top Player: Mike Lewis
Top Score: 7,855
Categories: Design, Overall
This is the fifth puzzle in the designable linker series! We are providing parts of two of the best-known designed binders to the SARS-CoV-2 spike, and are challenging players to link them together with a rigid linker! The two helical bundles are the parts of the two binders. They are currently connected with a flexible alanine linker that needs to be redesigned. Note that this puzzle has as different starting structure than previous puzzles and is about linking a different pair of the same binders.
Puzzle
Expired: 12/31/20 23:00:00
1 comment
Top Group: Contenders
Top Player: WBarme1234
Top Score: 0
Categories:
This sandbox puzzle features a designed protein linker for two CoV spike binders, by Jumper2, Mike Lewis, and Enzyme, from Puzzle 1912b. The designed linker region makes lots of contacts with both of the regions that it connects. More buried hydrophobics would make this linker even more rigid! For more, check out Foldit Lab Report #15 on YouTube! This sandbox puzzle is non-competitive and will not award any points.
Puzzle
Expired: 12/04/20 23:00:00
7 comments
Top Group: Go Science
Top Player: mirp
Top Score: 14,964
Categories: Design, Overall
Design a binder for the viral spike of MERS-CoV! This puzzle does not use the new Contact Surface Objective and is more similar to the previous Round 4 puzzle, except that the Metrics bonuses have been scaled down significantly. In this puzzle, the Metrics have a ramped bonus; as you improve DDG, SASA, and SC, you will get an increasing bonus until you reach the threshold of DDG < -40, SASA > 1500, and SC > 0.6, and then the bonus will be capped. Remember that Metrics are slow to compute and run in the background, so gameplay may be different from regular puzzles. See the blog for more info about Foldit Metrics.
Puzzle
Expired: 12/03/20 18:00:00
1 comment
Top Group: Go Science
Top Player: dcrwheeler
Top Score: 12,046
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. The function of this thermophilic protein is unknown, but it is unusual among intracellular proteins in that the native structure includes disulfide bonds. This protein contains six cysteine residues that are oxidized to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons