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Puzzle
Expired: 05/02/18 23:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 13,970
Categories: Design, Overall
Redesign the active site to bind aflatoxin! This puzzle uses the same starting structure as Round 7 of the Aflatoxin Challenge, but now players may insert up to 20 extra residues into the designable loops, at a cost of 20 points per residue. Parts of the scaffold protein have been trimmed to reduce the size of the puzzle, and we've upweighted ligand interactions by a factor of five. We'd like to see if Foldit players can design proteins that make more interactions with the ligand! See the blog for more details.
Puzzle
Expired: 04/24/18 23:00:00
2 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,965
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 65-75 residues. The starting structure has 65 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 04/23/18 18:00:00
1 comment
Top Group: Beta Folders
Top Player: reefyrob
Top Score: 12,707
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein binds fatty acids in intestinal cells. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 05/24/18 23:00:00
Top Group: Hun-Magyar Csapat
Top Player: Ribo-soma
Top Score: 16,741
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expired: 04/17/18 23:00:00
8 comments
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 33,816
Categories: Design, Overall
Note: This puzzle replaces Puzzle 1507, which was posted with an erroneous puzzle setup. Unfortunately, players will not be able to load solutions from the original Puzzle 1507.
Puzzle
Expired: 04/17/18 23:00:00
3 comments
Top Group: Gargleblasters
Top Player: dcrwheeler
Top Score: 33,201
Categories:
Design a protein that could be used as a vaccine for malaria! Malaria is a deadly disease caused by the parasite P. falciparum, which makes circumsporozoite protein (CSP) to grow and infect human cells. The human immune system can combat malaria by producing antibodies that recognize CSP on the surface of the parasite. However, the immune system is not always successful, in part because CSP is a highly flexible protein that can exchange between different structures. It was recently discovered that human antibodies can protect against malarial infection if they bind to a CSP loop in a particular "vulnerable" structure; but antibodies targeting alternative structures of CSP do not halt infection. If we can design a protein that contains the CSP loop in the vulnerable conformation, the protein could be used as a vaccine to prepare the immune system against malaria (by raising antibodies that bind the vulnerable CSP structure)!
Puzzle
Expired: 04/16/18 18:00:00
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 10,156
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small, intracellular domain binds to the CD2 T cell receptor (TCR), and plays a critical role in T cell activation during the immune response. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 05/17/18 23:00:00
Top Group: Hun-Magyar Csapat
Top Player: Ribo-soma
Top Score: 10,550
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expired: 04/18/18 23:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 13,845
Categories: Design, Overall
The Siegel Lab has identified a new protein scaffold that could potentially serve to degrade aflatoxin! This puzzle uses a different starting structure than Rounds 1-6 of the Aflatoxin Challenge, but the goal is the same: Redesign the active site to bind aflatoxin! Note that loop residues 62-69 in the starting structure clash with the aflatoxin molecule. Although residue insertions are not allowed in this puzzle, players may remove residues from this loop. Parts of the scaffold protein have been trimmed to reduce the size of the puzzle, and we've upweighted ligand interactions by a factor of five. We'd like to see if Foldit players can design proteins that make more interactions with the ligand! See the blog for more details.
Puzzle
Expired: 04/10/18 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 11,942
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons