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Puzzle
Expired: 06/30/21 23:00:00
3 comments
Top Group: Contenders
Top Player: CharlieFortsCon...
Top Score: 25,315
Categories: Design, Overall, Symmetry
Design a D2 symmetric protein tetramer, with 4 identical chains of 60 residues each! Unlike the cyclical C4 symmetry that we are used to, the proteins in this puzzle will come together as a "dimer of dimers" with D2 symmetry. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 06/25/21 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,691
Categories: Design, Overall
Design a protein that can bind to the TGF-beta receptor! We have been seeing excellent designs from the previous puzzles, so this puzzle is set up just the same. Try to max out the Contact Surface Objective by using sidechains that pack closely against the target binding site!
Puzzle
Expired: 06/24/21 18:00:00
10 comments
Top Group: Go Science
Top Player: mirp
Top Score: 28,933
Categories: Electron Density, Overall, Prediction
Fold this Transcription factor (TF) into the electron density map! This puzzle might be tough, as this is a large protein. This electron density map comes from x-ray crystallography experiments, and outlines the shape of the folded protein, so help us determine the structure of this TF by folding it in the electron density! Sequence and additional information in the puzzle comments.
Puzzle
Expired: 06/23/21 23:00:00
1 comment
Top Group: Contenders
Top Player: CharlieFortsCon...
Top Score: 26,325
Categories: Design, Overall, Symmetry
Design a D2 symmetric protein tetramer, with 4 identical chains of 60 residues each! Unlike the cyclical C4 symmetry that we are used to, the proteins in this puzzle will come together as a "dimer of dimers" with D2 symmetry. This puzzle has no H-Bond Network Objective, but there is "Core Limit: Complex" objective meant to regulate the size of the interface between symmetric chains. An interface that is too large, with too many orange hydrophobics, can prevent the individual subunits from folding properly; on the other hand, an interface that is too small does not provide enough interactions for assembly The "Core Limit: Complex" objective will incur penalties if there are too many, or too few buried residues in the total assembly. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. See the puzzle comments for more Objective details.
Puzzle
Expired: 06/18/21 23:00:00
1 comment
Top Group: Beta Folders
Top Player: Crossed Sticks
Top Score: 13,647
Categories: Design, Overall
Note: This puzzle replaces the original Puzzle 2005 which used a mis-calibrated score function. Players may load in solutions from the original Puzzle 2005.
Puzzle
Expired: 06/18/21 23:00:00
3 comments
Top Group: Anthropic Dreams
Top Player: stomjoh
Top Score: 0
Categories:
Note: This puzzle was closed early due to scoring problems and reposted as Puzzle 2005b. Players may save any work from this puzzle and load it into the reposted Puzzle 2005b.
Puzzle
Expired: 06/17/21 18:00:00
Top Group: Anthropic Dreams
Top Player: grogar7
Top Score: 10,529
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This DNA-binding domain is part of a bacterial integrase protein, which facilitates the insertion of new DNA into the bacterial chromosome. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 06/16/21 23:00:00
1 comment
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 31,968
Categories: Design, Overall, Symmetry
Design a D2 symmetric protein tetramer, with 4 identical chains of 90 residues each! Unlike the cyclical C4 symmetry that we are used to, the proteins in this puzzle will come together as a "dimer of dimers" with D2 symmetry. This puzzle has no H-Bond Network Objective, but there is "Core Limit: Complex" objective meant to regulate the size of the interface between symmetric chains. An interface that is too large, with too many orange hydrophobics, can prevent the individual subunits from folding properly; on the other hand, an interface that is too small does not provide enough interactions for assembly The "Core Limit: Complex" objective will incur penalties if there are too many, or too few buried residues in the total assembly. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. See the puzzle comments for more Objective details.
Puzzle
Expired: 06/11/21 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,707
Categories: Design, Overall
Design a protein that can bind to the TGF-beta receptor! We have been seeing excellent designs from the previous puzzles, so this puzzle is set up just the same. Try to max out the Contact Surface Objective by using sidechains that pack closely against the target binding site!
Puzzle
Expired: 06/10/21 18:00:00
1 comment
Top Group: Beta Folders
Top Player: sallallami
Top Score: 10,253
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein helps to transfer electrons between substrates in bacteria. The protein is modeled here in reducing conditions, and no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons