Puzzles Feed

Closed

Puzzle
Expired: 05/07/20 23:00:00
2 comments
Top Group: Hold My Beer
Top Player: Steven Pletsch
Top Score: 10,106
Categories: Overall, Prediction
Refold the loops in this Aflatoxin Challenge design! This is a followup to Round 15, this time starting with a completely unfolded loop. Previously, Foldit players had redesigned the binding loops of an oxidation enzyme, and testing at the Siegel Lab found that some designs had high oxidative activity for other molecules--but no activity against aflatoxin! We think the redesigned loops might be misfolding when aflatoxin is not in the binding pocket. Misfolded loops could prevent the enzyme from binding aflatoxin and catalyzing the oxidation reaction. We wonder if Foldit players can predict how these binding loops might misfold, by refolding the loops in ways that score better than the original design. If we can figure out how the binding loops misfold, then we might be able to fix them and recover activity against aflatoxin!
Puzzle
Expired: 05/08/20 18:00:00
2 comments
Top Group: Go Science
Top Player: Dhalion
Top Score: 11,271
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin is produced in the intestines of the African black mamba. The protein contains ten cysteines that oxidize to form five disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 05/06/20 23:00:00
7 comments
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 14,882
Categories: Design, Overall
Design a binder against coronavirus! This puzzle is similar to Rounds 1 and 2 of our Coronavirus Binder Design challenge. but with tighter limits on the allowed number of segments. The starting structure has 177 segments, and players may use no more than 182 total. See the Foldit blog for tips on making a successful protein binder!
Puzzle
Expired: 04/29/20 23:00:00
5 comments
Top Group: Go Science
Top Player: mirp
Top Score: 12,841
Categories: Design, Overall
Note: This puzzle replaces Puzzle 1828, which had some errors in the protein backbone. Players may load solutions saved in Puzzle 1828.
Puzzle
Expired: 05/01/20 18:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,885
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is an allergen produced by the white birch tree. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 04/30/20 23:00:00
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 10,160
Categories: Overall, Prediction
Refold the loops in this Aflatoxin Challenge design! This is a followup to Round 14, this time starting with a completely unfolded loop. Previously, Foldit players had redesigned the binding loops of an oxidation enzyme, and testing at the Siegel Lab found that some designs had high oxidative activity for other molecules--but no activity against aflatoxin! We think the redesigned loops might be misfolding when aflatoxin is not in the binding pocket. Misfolded loops could prevent the enzyme from binding aflatoxin and catalyzing the oxidation reaction. We wonder if Foldit players can predict how these binding loops might misfold, by refolding the loops in ways that score better than the original design. If we can figure out how the binding loops misfold, then we might be able to fix them and recover activity against aflatoxin!
Puzzle
Expired: 04/29/20 23:00:00
7 comments
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 12,389
Categories:
Note: This puzzle was closed early due to some problems with the protein backbone, and a corrected version was reposted as Puzzle 1828b. Players may load their saved solutions into the reposted puzzle.
Puzzle
Expired: 04/24/20 18:00:00
1 comment
Top Group: Beta Folders
Top Player: Angus
Top Score: 10,682
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This particular protein is known as ubiquitin, and plays a prominent role in the protein degradation pathway. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 04/23/20 23:00:00
20 comments
Top Group: Go Science
Top Player: fiendish_ghoul
Top Score: 10,350
Categories: Overall, Prediction
This is a follow-up to Puzzle 1823, but players noticed that the first 15 amino acids are highly predicted to be a signal peptide, so we have trimmed those residues from this puzzle. This protein is encoded in the viral genome of SARS-CoV-2, but the protein's structure is still unknown. If we knew how this protein folds, we might be able to figure out its exact function. Refold this different starting model to find higher-scoring solutions, which will tell us how this protein is most likely to fold!
Puzzle
Expired: 04/22/20 23:00:00
6 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 16,343
Categories: Design, Overall
Design a binder against coronavirus! We're challenging players to design an antiviral protein that could bind to the 2019 coronavirus spike protein and disrupt viral infection. The starting structure is a solution designed by Susume in our previous Round 3 puzzle. This solution makes an excellent interface with the target, but we're concerned that the binder may not fold properly, especially the loops connecting the three helices. We're asking Foldit players to try and improve this design so that it folds up correctly and can bind to the target! Players also have freedom to redesign an entirely new solution from scratch.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons