Puzzles Feed

Closed

Puzzle
Expired: 10/11/18 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 12,569
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 65-75 residues. The starting structure has 65 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 10/05/18 23:00:00
2 comments
Top Group: Go Science
Top Player: toshiue
Top Score: 11,050
Categories: Overall, Prediction
This is a repost of Partition Puzzle (B): fiendish_ghoul, which is part of the Protein Design Partition Tournament. Unlike the previous puzzle, this repost is for points, and will count in the Overall and Prediction categories. The starting structure is a protein designed by fiendish_ghoul. We are challenging Foldit players to refold the designed protein, to try to find high-scoring decoy structures. This puzzle includes an RMSD Objective, which requires all solutions to be different from the starting structure with an RMSD of at least 2.5 Å. Players that have participated in the original Partition Puzzle will be able to load solutions into this puzzle. Note that this puzzle will only be available for a short time, and will expire on October 5.
Puzzle
Expired: 10/09/18 10:00:00
7 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 12,452
Categories: Overall, Prediction
This bigger protein is another part of the same protein complex with multiple subunits from Puzzle 1554, which has been the target of cryo-EM experiments. We are giving you 5 different server predictions as starting points. Reset the puzzle to cycle through the different starting models.
Puzzle
Expired: 10/04/18 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 13,158
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 10/03/18 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,770
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein, which inhibits muscle contraction in the absence of calcium ions, changes conformation in the presence of calcium to allow muscle contraction. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/26/18 11:59:00
5 comments
Top Group: Go Science
Top Player: isaksson
Top Score: 18,569
Categories: Electron Density, Overall, Prediction
This is a repost of Puzzle 1572, which was unable to load solutions from the previous Puzzle 1554. Players may now load solutions from Puzzle 1554, as well as any work in the original Puzzle 1572. NOTE: If you did not manually save a solution in 1554 or 1572, you can go back to either puzzle, manually save it, and the solution should appear in your manual saves for this puzzle.
Puzzle
Expired: 09/27/18 23:00:00
4 comments
Top Group: Gargleblasters
Top Player: ManVsYard
Top Score: 14,001
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 09/26/18 18:00:00
1 comment
Top Group: Marvin's bunch
Top Player: hpaege
Top Score: 10,112
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin is found in green mamba venom, and blocks the flow of calcium ions that normally depolarize the muscle cell to induce muscle contraction. This protein contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 10/16/18 23:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 10,631
Categories:
This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by silent gene from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.
Puzzle
Expired: 10/15/18 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,026
Categories:
Note: This puzzle was closed early, because challengers found decoy states with lower energy than the initial design. Try one of the other partition puzzles!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons