Puzzles Feed

Current

Puzzle
Expires: 09/20/18 23:00:00
1 comment
Top Group: Beta Folders
Top Player: johnmitch
Top Score: 12,137
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 09/19/18 18:00:00
17 comments
Top Group: Go Science
Top Player: Hollinas
Top Score: 20,781
Categories: Small Molecule Design

Due to reports of persistent crashing and issues with loading/saving solutions, we've changed this puzzle to be worth zero points. We're leaving it open, though, for those people who still want to play around with it.

Closed

Puzzle
Expired: 10/15/18 23:00:00
Top Group: Go Science
Top Player: ReallyRatherDumb
Top Score: 10,181
Categories:
This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by silent gene from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.
Puzzle
Expired: 10/15/18 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 9,703
Categories:
This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by MicElephant from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.
Puzzle
Expired: 10/15/18 23:00:00
Top Group: Gargleblasters
Top Player: Skippysk8s
Top Score: 10,024
Categories:
This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by fiendish_ghoul from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.
Puzzle
Expired: 10/15/18 23:00:00
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 11,043
Categories:
This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by actiasluna from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.
Puzzle
Expired: 10/15/18 23:00:00
Top Group: Go Science
Top Player: ReallyRatherDumb
Top Score: 9,472
Categories:
This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by robgee from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.
Puzzle
Expired: 10/15/18 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,551
Categories:
This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by Skippysk8s from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.
Puzzle
Expired: 10/15/18 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 9,895
Categories:
This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by ManVsYard from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.
Puzzle
Expired: 10/15/18 23:00:00
Top Group: Marvin's bunch
Top Player: frood66
Top Score: 10,845
Categories:
This is a partition puzzle for Phase Two of the Partition Tournament! The starting structure is a design by Newton76 from Phase One of the tournament, and is now vulnerable to challenges. Players can challenge the design by playing this puzzle and refolding the starting structure into other high-scoring structures. The starting structure is marked with secondary structure predictions from PSIPRED, and may give clues about how this protein could be refolded. This design will ultimately be evaluated by how well it withstands challenges, as measured by the partition function. See the blog for more details about the Protein Design Partition Tournament.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons