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Puzzle
Expired: 05/29/18 23:00:00
2 comments
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 18,319
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C2 symmetry, with two symmetric chains. The H-bond Network Filter encourages players to bury satisfied H-bond networks at the interface between the two chains. There a couple other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 05/28/18 18:00:00
Top Group: Beta Folders
Top Player: bertro
Top Score: 10,279
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein helps to transfer electrons between substrates in bacteria. The protein is modeled here in reducing conditions, and no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 05/23/18 23:00:00
Top Group: Beta Folders
Top Player: retiredmichael
Top Score: 11,153
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 05/22/18 23:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 17,103
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C2 symmetry, with two symmetric chains. The H-bond Network Filter encourages players to bury satisfied H-bond networks at the interface between the two chains. There a couple other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 05/21/18 18:00:00
1 comment
Top Group: Void Crushers
Top Player: Neil9
Top Score: 11,804
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This human protein helps to regulate the reduction potential of the cell, and should be modeled here in reduced form (with no disulfide bonds). We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 06/21/18 23:00:00
Top Group: :)
Top Player: thewholeblahthing
Top Score: 9,103
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expired: 05/15/18 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 12,000
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 05/16/18 23:00:00
25 comments
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 13,973
Categories:
Note: Due to player reports of persistent crashing, this puzzle is now worth zero points, so players may skip this puzzle without any effect on their rankings. However, if players would like to continue playing the puzzle, we will still analyze the puzzle solutions. And of course, we appreciate all of the detailed feedback about the puzzle!
Puzzle
Expired: 05/14/18 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 11,252
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This spinach protein is critical for photosynthesis, and participates in the electron transfer chain within the chloroplast. The protein is modeled here in the reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 06/14/18 23:00:00
Top Group: :)
Top Player: MicElephant
Top Score: 9,211
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons