Puzzles Feed

Closed

Puzzle
Expired: 09/17/19 23:00:00
3 comments
Top Group: Go Science
Top Player: Phyx
Top Score: 11,458
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 09/18/19 23:00:00
1 comment
Top Group: Marvin's bunch
Top Player: dcrwheeler
Top Score: 17,689
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C2 symmetry, with two symmetric chains. No more than 50% of residues may form helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. We've omitted the "Core Exists: Complex" objective to simplify the puzzle, but we still expect that designs with a strong hydrophobic interface (orange sidechains) will score best. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 09/13/19 23:00:00
2 comments
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 11,888
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 09/16/19 18:00:00
1 comment
Top Group: Marvin's bunch
Top Player: jausmh
Top Score: 10,992
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This is another potent neurotoxin produced by scorpions, similar to that found in Puzzle 55. This protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/09/19 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 11,993
Categories: Design, Overall
Design a protein that binds IL-7R!
Puzzle
Expired: 09/11/19 23:00:00
4 comments
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 20,356
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C3 symmetry, with three symmetric chains. This puzzle is a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the chains. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 09/05/19 23:00:00
3 comments
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 11,846
Categories: Design, Overall
Note: This puzzle replaces the original Puzzle 1723, which was incorrectly set up to allow free movement of the binding helices. Unfortunately, players will not be allowed to load solutions from the original Puzzle 1723.
Puzzle
Expired: 09/09/19 18:00:00
1 comment
Top Group: Hun-Magyar Csapat
Top Player: O Seki To
Top Score: 10,728
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This cow protein, found in epithelial cells of the intestine, binds calcium as it moves from the digestive tract into the blood. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/05/19 23:00:00
3 comments
Top Group: Go Science
Top Player: silent gene
Top Score: 11,635
Categories:
Note: This puzzle was closed early, due to an error in the puzzle setup that allowed free movement of the IL-7R binding helices. The puzzle has been reposted as Puzzle 1723b.
Puzzle
Expired: 09/04/19 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 17,108
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C3 symmetry, with three symmetric chains. This puzzle is a little different from other symmetry puzzles, in that we want players to focus on building a smaller interface between the chains. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons