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Puzzle
Expired: 04/15/21 18:00:00
Top Group: Contenders
Top Player: georg137
Top Score: 11,716
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein was designed by the Baker Lab in 2003, and has a topology unlike any natural protein yet discovered. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 04/14/21 23:00:00
6 comments
Top Group: Go Science
Top Player: toshiue
Top Score: 23,052
Categories: Design, Overall, Symmetry
Design a symmetric protein tetramer, with 4 identical chains that assemble together! This puzzle includes a Secondary Structure Objective, so no more than 50% of your design can form helices. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 04/09/21 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 11,009
Categories: Design, Overall
Design a protein to bind to influenza virus! This puzzle is set up just like Puzzle 1968. Although there is no competition this time for the players who submit the most solutions, you are still encouraged to restart the puzzle once you reach 10,000 points. The more designs we have to test, the better our chances at finding a successful binder for influenza HA!
Puzzle
Expired: 04/08/21 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 12,819
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein binds fatty acids in intestinal cells. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 04/30/21 23:00:00
Top Group: L'Alliance Francophone
Top Player: blazegeek
Top Score: 10,639
Categories:
This sandbox puzzle features three solutions submitted by LociOiling for our Influenza HA Binder Design Competition. Reset the puzzle to cycle through the three different designs. All of these designed binders look like they have a good chance of folding correctly, and orange hydrophobic residues at the target interface will make for tight binding. Look out for blue polar sidechains on the target that are buried by the binder; if the binder does not make H-bonds with the polar atoms on these sidechains, they will become unstable BUNS and prevent binding! For more, check out Foldit Lab Report #19 on YouTube! This sandbox puzzle is non-competitive and will not award any points.
Puzzle
Expired: 04/07/21 23:00:00
1 comment
Top Group: Contenders
Top Player: BootsMcGraw
Top Score: 20,165
Categories: Design, Overall, Symmetry
Design a symmetric protein tetramer, with 4 identical chains that assemble together! This puzzle includes a Secondary Structure Objective, so no more than 50% of your design can form helices. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 04/02/21 23:00:00
2 comments
Top Group: Go Science
Top Player: toshiue
Top Score: 10,003
Categories: Design, Overall
Design a protein to bind to the Tie2 receptor! Tie2 is a human protein that helps to regulate the maintenance and growth of blood vessels throughout the body. Normally, the Tie2 receptor binds a growth factor called angiopoietin, a signaling molecule that triggers the growth of new blood vessels. However, Tie2 overactivity has been implicated in several types of cancer, since rapidly-growing tumors require lots of new blood vessels to provide nutrients. We want to design a protein that could bind to Tie2 and block angiopoietin. A successful binder might be useful as a drug to modulate Tie2 activity that is necessary for tumor growth.
Puzzle
Expired: 04/01/21 18:00:00
2 comments
Top Group: Go Science
Top Player: fiendish_ghoul
Top Score: 17,837
Categories: Electron Density, Overall, Prediction
Fold this CMG2 protein into the electron density map! This protein is a domain of the human capillary morphogenesis protein 2 (CMG2). The CMG2 protein normally associates with other proteins in connective tissue, and is thought to be important for the formation of new blood vessels. But CMG2 is also targeted by the anthrax toxin, and has been implicated in certain types of cancer. The protein in this puzzle is a variant of CMG2 that researchers are studying to better understand its structure and function. This electron density map comes from x-ray crystallography experiments, and outlines the shape of the folded protein. Help us determine the structure of this CMG2 variant by folding it in the electron density!
Puzzle
Expired: 03/31/21 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 24,012
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains that assemble together! This puzzle includes a Secondary Structure Objective, so no more than 50% of your design can form helices. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 03/25/21 18:00:00
1 comment
Top Group: Go Science
Top Player: toshiue
Top Score: 10,135
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small, intracellular domain binds to the CD2 T cell receptor (TCR), and plays a critical role in T cell activation during the immune response. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons