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Puzzle
Expired: 06/09/21 23:00:00
3 comments
Top Group: Go Science
Top Player: silent gene
Top Score: 26,393
Categories: Design, Overall, Symmetry
Design a D2 symmetric protein tetramer, with 4 identical chains of 70 residues each! Unlike the cyclical C4 symmetry that we are used to, the proteins in this puzzle will come together as a "dimer of dimers" with D2 symmetry. This puzzle has no H-Bond Network Objective, but there is "Core Limit: Complex" objective meant to regulate the size of the interface between symmetric chains. An interface that is too large, with too many orange hydrophobics, can prevent the individual subunits from folding properly; on the other hand, an interface that is too small does not provide enough interactions for assembly The "Core Limit: Complex" objective will incur penalties if there are too many, or too few buried residues in the total assembly. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. See the puzzle comments for more Objective details.
Puzzle
Expired: 06/04/21 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,786
Categories: Design, Overall
Design a protein to bind to the Tie2 receptor! We saw lots of great designs in the previous Round 3 puzzle, so this puzzle is set up just the same. Try to max out the Contact Surface Objective by using sidechains that pack closely against the target binding site!
Puzzle
Expired: 06/02/21 23:00:00
4 comments
Top Group: Go Science
Top Player: dcrwheeler
Top Score: 28,874
Categories: Design, Overall, Symmetry
Design a D2 symmetric protein tetramer, with 4 identical chains of 80 residues each! Unlike the cyclical C4 symmetry that we are used to, the proteins in this puzzle will come together as a "dimer of dimers" with D2 symmetry. This puzzle has no H-Bond Network Objective, but there is "Core Limit: Complex" objective meant to limit the size of the interface between symmetric chains. An interface that is too large, with too many orange hydrophobics, can prevent the individual subunits from folding properly. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. See the puzzle comments for more Objective details.
Puzzle
Expired: 05/28/21 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,989
Categories: Design, Overall
Design a protein that can bind to the TGF-beta receptor! We saw some excellent designs in the previous Round 3 puzzle, so this puzzle is set up just the same. Try to max out the Contact Surface Objective by using sidechains that pack closely against the target binding site!
Puzzle
Expired: 06/03/21 18:00:00
7 comments
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 13,843
Categories: Overall, Prediction
Scientists at UC Santa Cruz need your help! They have been unable to solve the structure of the human astrovirus (HAstV) capsid protein, which is involved in host cell receptor binding. They have some experimental data about the protein structure, but have been unable to find a model that explains the experimental data. This is a multi-start puzzle, with 5 different starting structures provided by the Zhang structure prediction server. Reset the puzzle to cycle through the different starting models. We are giving you 2 weeks to try out all 5 starting models.
Puzzle
Expired: 05/26/21 23:00:00
7 comments
Top Group: Contenders
Top Player: georg137
Top Score: 19,532
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains of 60 residues each! This puzzle includes a Secondary Structure Objective, so no more than 50% of your design can form helices. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 05/21/21 23:00:00
1 comment
Top Group: Go Science
Top Player: toshiue
Top Score: 10,718
Categories: Design, Overall
Design a protein to bind to influenza virus! This puzzle is set up similar to the Round 5, but we've increased the Contact Surface goal to 500.
Puzzle
Expired: 05/20/21 18:00:00
Top Group: Go Science
Top Player: mirp
Top Score: 11,805
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This human protein helps to regulate the reduction potential of the cell, and should be modeled here in reduced form (with no disulfide bonds). We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 05/19/21 23:00:00
14 comments
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 25,833
Categories: Design, Overall, Symmetry
Design a D2 symmetric protein tetramer, with 4 identical chains that assemble together! Unlike the cyclical C4 symmetry that we are used to, the proteins in this puzzle will come together as a "dimer of dimers" with D2 symmetry. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 05/14/21 23:00:00
1 comment
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 10,882
Categories: Design, Overall
Design a protein that can bind to the TGF-beta receptor! We saw some excellent designs in the previous Round 2 puzzle, so this puzzle is set up just the same. Try to max out the Contact Surface Objective by using sidechains that pack closely against the target binding site!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons