Puzzles Feed

Closed

Puzzle
Expired: 11/04/18 23:00:00
6 comments
Top Group: Go Science
Top Player: Maerlyn138
Top Score: 11,750
Categories:
Note: This puzzle was closed early, due to some continuing scoring issues, and reposted as Puzzle 1590c.
Puzzle
Expired: 10/26/18 18:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 10,364
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin, produced by the Chinese cobra N. atra, induces contracture in skeletal and cardiac muscle. This protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 10/24/18 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 12,116
Categories: Design, Overall
This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 11/03/18 08:00:00
4 comments
Top Group: Go Science
Top Player: isaksson
Top Score: 22,359
Categories: Electron Density, Overall, Prediction
This is a repost of Puzzle 1579, now with electron density! Load in your Puzzle 1579 solutions and see if you can improve them to fit the density! We are giving you the same 5 server predictions as starting points, and over TWO WEEKS to work on this difficult target. Read the blogpost for more details.
Puzzle
Expired: 10/18/18 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,439
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin, produced by the Mozambique spitting cobra, induces contracture in skeletal and cardiac muscle. This protein contains eight cysteine residues, which oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 10/13/18 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 11,620
Categories: Overall, Prediction
This is a repost of Partition Puzzle (B): LociOiling, which is part of the Protein Design Partition Tournament. Unlike the previous puzzle, this repost is for points, and will count in the Overall and Prediction categories. The starting structure is a protein designed by LociOiling. We are challenging Foldit players to refold the designed protein, to try to find high-scoring decoy structures. This puzzle includes an RMSD Objective, which requires all solutions to be different from the starting structure with an RMSD of at least 2.5 Å. Players that have participated in the original Partition Puzzle will be able to load solutions into this puzzle. Note that this puzzle will only be available for a short time, and will expire on October 13.
Puzzle
Expired: 10/15/18 23:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 12,025
Categories: Overall, Prediction
This is a repost of Partition Puzzle (B): matosfran, which is part of the Protein Design Partition Tournament. Unlike the previous puzzle, this repost is for points, and will count in the Overall and Prediction categories. The starting structure is a protein designed by matosfran. We are challenging Foldit players to refold the designed protein, to try to find high-scoring decoy structures. This puzzle includes an RMSD Objective, which requires all solutions to be different from the starting structure with an RMSD of at least 2.5 Å. Players that have participated in the original Partition Puzzle will be able to load solutions into this puzzle. Note that this puzzle will only be available for a short time, and will expire on October 15.
Puzzle
Expired: 10/14/18 23:00:00
Top Group: Beta Folders
Top Player: smilingone
Top Score: 11,936
Categories: Overall, Prediction
This is a repost of Partition Puzzle (B): actiasluna, which is part of the Protein Design Partition Tournament. Unlike the previous puzzle, this repost is for points, and will count in the Overall and Prediction categories. The starting structure is a protein designed by actiasluna. We are challenging Foldit players to refold the designed protein, to try to find high-scoring decoy structures. This puzzle includes an RMSD Objective, which requires all solutions to be different from the starting structure with an RMSD of at least 2.5 Å. Players that have participated in the original Partition Puzzle will be able to load solutions into this puzzle. Note that this puzzle will only be available for a short time, and will expire on October 14.
Puzzle
Expired: 10/16/18 23:00:00
Top Group: Gargleblasters
Top Player: Glen B
Top Score: 12,004
Categories: Overall, Prediction
This is a repost of Partition Puzzle (B): Galaxie, which is part of the Protein Design Partition Tournament. Unlike the previous puzzle, this repost is for points, and will count in the Overall and Prediction categories. The starting structure is a protein designed by Galaxie. We are challenging Foldit players to refold the designed protein, to try to find high-scoring decoy structures. This puzzle includes an RMSD Objective, which requires all solutions to be different from the starting structure with an RMSD of at least 2.5 Å. Players that have participated in the original Partition Puzzle will be able to load solutions into this puzzle. Note that this puzzle will only be available for a short time, and will expire on October 16.
Puzzle
Expired: 10/09/18 23:00:00
1 comment
Top Group: Beta Folders
Top Player: hpaege
Top Score: 11,484
Categories: Overall, Prediction
This is a repost of Partition Puzzle (B): wisky, which is part of the Protein Design Partition Tournament. Unlike the previous puzzle, this repost is for points, and will count in the Overall and Prediction categories. The starting structure is a protein designed by wisky. We are challenging Foldit players to refold the designed protein, to try to find high-scoring decoy structures. This puzzle includes an RMSD Objective, which requires all solutions to be different from the starting structure with an RMSD of at least 2.5 Å. Players that have participated in the original Partition Puzzle will be able to load solutions into this puzzle. Note that this puzzle will only be available for a short time, and will expire on October 9.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons