Closed

Note: This puzzle was closed early, due to some continuing scoring issues, and reposted as Puzzle 1590c.

This is a throwback puzzle to the early days of Foldit. This toxin, produced by the Chinese cobra N. atra, induces contracture in skeletal and cardiac muscle. This protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

This is a repost of Puzzle 1579, now with electron density! Load in your Puzzle 1579 solutions and see if you can improve them to fit the density! We are giving you the same 5 server predictions as starting points, and over TWO WEEKS to work on this difficult target. Read the blogpost for more details.

This is a throwback puzzle to the early days of Foldit. This toxin, produced by the Mozambique spitting cobra, induces contracture in skeletal and cardiac muscle. This protein contains eight cysteine residues, which oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

This is a repost of Partition Puzzle (B): LociOiling, which is part of the Protein Design Partition Tournament. Unlike the previous puzzle, this repost is for points, and will count in the Overall and Prediction categories. The starting structure is a protein designed by LociOiling. We are challenging Foldit players to refold the designed protein, to try to find high-scoring decoy structures. This puzzle includes an RMSD Objective, which requires all solutions to be different from the starting structure with an RMSD of at least 2.5 Å. Players that have participated in the original Partition Puzzle will be able to load solutions into this puzzle. Note that this puzzle will only be available for a short time, and will expire on October 13.

This is a repost of Partition Puzzle (B): matosfran, which is part of the Protein Design Partition Tournament. Unlike the previous puzzle, this repost is for points, and will count in the Overall and Prediction categories. The starting structure is a protein designed by matosfran. We are challenging Foldit players to refold the designed protein, to try to find high-scoring decoy structures. This puzzle includes an RMSD Objective, which requires all solutions to be different from the starting structure with an RMSD of at least 2.5 Å. Players that have participated in the original Partition Puzzle will be able to load solutions into this puzzle. Note that this puzzle will only be available for a short time, and will expire on October 15.

This is a repost of Partition Puzzle (B): actiasluna, which is part of the Protein Design Partition Tournament. Unlike the previous puzzle, this repost is for points, and will count in the Overall and Prediction categories. The starting structure is a protein designed by actiasluna. We are challenging Foldit players to refold the designed protein, to try to find high-scoring decoy structures. This puzzle includes an RMSD Objective, which requires all solutions to be different from the starting structure with an RMSD of at least 2.5 Å. Players that have participated in the original Partition Puzzle will be able to load solutions into this puzzle. Note that this puzzle will only be available for a short time, and will expire on October 14.

This is a repost of Partition Puzzle (B): Galaxie, which is part of the Protein Design Partition Tournament. Unlike the previous puzzle, this repost is for points, and will count in the Overall and Prediction categories. The starting structure is a protein designed by Galaxie. We are challenging Foldit players to refold the designed protein, to try to find high-scoring decoy structures. This puzzle includes an RMSD Objective, which requires all solutions to be different from the starting structure with an RMSD of at least 2.5 Å. Players that have participated in the original Partition Puzzle will be able to load solutions into this puzzle. Note that this puzzle will only be available for a short time, and will expire on October 16.

This is a repost of Partition Puzzle (B): wisky, which is part of the Protein Design Partition Tournament. Unlike the previous puzzle, this repost is for points, and will count in the Overall and Prediction categories. The starting structure is a protein designed by wisky. We are challenging Foldit players to refold the designed protein, to try to find high-scoring decoy structures. This puzzle includes an RMSD Objective, which requires all solutions to be different from the starting structure with an RMSD of at least 2.5 Å. Players that have participated in the original Partition Puzzle will be able to load solutions into this puzzle. Note that this puzzle will only be available for a short time, and will expire on October 9.