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Puzzle
Expired: 05/06/22 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 14,329
Categories: Design, Overall
Design a protein that can bind to CD22! This puzzle has a reduced BUNS penalty so that players can focus on other Objectives--but don't forget about BUNS completely! This puzzle enables AlphaFold predictions for your designed binder. Once you've designed a binder for the target, upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your binder chain only (i.e. in the unbound state, in the absence of the target). If you load this prediction, then Foldit will attempt to align the prediction with your solution (i.e. in the bound state, making an interface with the target). If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the binder interacts with the target.
Puzzle
Expired: 05/05/22 18:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: LociOiling
Top Score: 11,903
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein helps to regulate the human immune response, and the starting structure is a Rosetta model. The protein is modeled here in the reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 05/04/22 23:00:00
2 comments
Top Group: Contenders
Top Player: Aubade01
Top Score: 23,655
Categories: Overall, Small Molecule Design
Design a small molecule which can bind to KLHDC2! We don't want you to modify the protein, but instead use the small molecule design tools to build new small molecules which fit into the KLHDC2 binding pocket.
Puzzle
Expired: 04/29/22 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 24,366
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains of 90 residues each! This puzzle enables AlphaFold predictions for the monomer subunit of your design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your monomer subunit only (i.e. in the unbound state, in the absence of other symmetric copies). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the monomer subunit interacts with symmetric copies.
Puzzle
Expired: 04/28/22 18:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 16,734
Categories: Electron Density, Overall, Prediction
The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. In addition to the protein chain, puzzle includes a glutathione ligand that is fixed in place.
Puzzle
Expired: 04/27/22 23:00:00
6 comments
Top Group: Contenders
Top Player: NeLikomSheet
Top Score: 23,020
Categories: Overall, Small Molecule Design
Design a small molecule which can bind to KLHDC2! We don't want you to modify the protein, but instead use the small molecule design tools to build new small molecules which fit into the KLHDC2 binding pocket.
Puzzle
Expired: 04/22/22 23:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 11,320
Categories: Design, Overall
Design a protein that can bind to the TGF-beta receptor! This puzzle has a reduced BUNS penalty so that players can focus on other Objectives--but don't forget about BUNS completely! AlphaFold predictions are available for your designed binder. Once you've designed a binder for the target, upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your binder chain only (i.e. in the unbound state, in the absence of the target). If you load this prediction, then Foldit will attempt to align the prediction with your solution (i.e. in the bound state, making an interface with the target). If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the binder interacts with the target.
Puzzle
Expired: 04/21/22 18:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,077
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small protein, from the venom of the saw-scaled viper, interferes with the cellular adhesion machinery that allows blood clotting. This protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 04/20/22 23:00:00
1 comment
Top Group: Contenders
Top Player: maithra
Top Score: 20,947
Categories: Design, Overall, Symmetry
Note: This puzzle will crash if a player uses the Cut tool. The Foldit team has tracked down the bug and will release a software update shortly. In the meantime, please avoid using the Cut tool on this puzzle!
Puzzle
Expired: 04/15/22 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 14,267
Categories: Design, Overall
Design a protein that can bind to CD47! This puzzle has a reduced BUNS penalty so that players can focus on other Objectives--but don't forget about BUNS completely! AlphaFold predictions are available for your designed binder. Once you've designed a binder for the target, upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your binder chain only (i.e. in the unbound state, in the absence of the target). If you load this prediction, then Foldit will attempt to align the prediction with your solution (i.e. in the bound state, making an interface with the target). If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the binder interacts with the target.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons