Puzzles Feed

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Puzzle
Expired: 06/21/18 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,800
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 06/19/18 23:00:00
3 comments
Top Group: Anthropic Dreams
Top Player: johnmitch
Top Score: 18,592
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C3 symmetry, with three symmetric chains. The H-bond Network Filter encourages players to bury satisfied H-bond networks at the interface between the three chains. We've doubled the H-bond network bonus, but we'd like players to focus on building networks deep in the core of the protein complex. There a couple other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 06/18/18 18:00:00
1 comment
Top Group: Beta Folders
Top Player: Glen B
Top Score: 11,156
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This is another potent neurotoxin produced by scorpions, similar to that found in Puzzle 55. This protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 06/14/18 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,709
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 06/12/18 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 17,330
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C3 symmetry, with three symmetric chains. The H-bond Network Filter encourages players to bury satisfied H-bond networks at the interface between the three chains. We've doubled the H-bond network bonus, but we'd like players to focus on building networks deep in the core of the protein complex. There a couple other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 06/11/18 18:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,751
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This cow protein, found in epithelial cells of the intestine, binds calcium as it moves from the digestive tract into the blood. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 06/07/18 23:00:00
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 10,760
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
Puzzle
Expired: 06/05/18 23:00:00
7 comments
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 17,036
Categories: Design, Overall, Symmetry
This symmetric design puzzle has C2 symmetry, with two symmetric chains. The H-bond Network Filter encourages players to bury satisfied H-bond networks at the interface between the two chains. We've doubled the H-bond network bonus, but we'd like players to focus on building networks deep in the core of the protein complex. There a couple other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expired: 06/04/18 18:00:00
1 comment
Top Group: Beta Folders
Top Player: smilingone
Top Score: 10,477
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This DNA-binding domain is part of a bacterial integrase protein, which facilitates the insertion of new DNA into the bacterial chromosome. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 05/31/18 23:00:00
Top Group: Gargleblasters
Top Player: actiasluna
Top Score: 10,107
Categories: Overall, Prediction
The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Microsoft, Adobe, RosettaCommons