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Puzzle
Expires: 01/24/20 23:00:00
1 comment
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 11,244
Categories: Design, Overall
This is the seventh puzzle in the poly-proline helix design series! The starting structure is an 80 reside protein with a 5 residue helix, and all residues are mutable. The reference weight fo proline has been changed from 16.4 to 30.0 to provide a small incentive for proline usage. Keeping good hydrophobic cores with any buried polars satisfied with hydrogen bonds will help create stable structures. Hydrogen bonds are visible by selecting 'Show advanced GUI' in General Options in the Menu tab, and then selecting 'Show bonds (loop)' and 'Show bondable atoms' in the View tab.
Puzzle
Expires: 01/23/20 23:00:00
3 comments
Top Group: Go Science
Top Player: toshiue
Top Score: 12,140
Categories: Overall, Prediction
Fold this transposase protein from a CRISPR-Cas complex! This puzzle presents the second half of the transposase protein, as a follow-up to Puzzle 1784: CRISPR-Cas Transposase Part I.
Puzzle
Expires: 01/22/20 18:00:00
1 comment
Top Group: Go Science
Top Player: silent gene
Top Score: 10,573
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is secreted at the site of inflammation, recruiting monocytes and T cells to help fight an infection. This protein contains four cysteine residues that oxidize to form two disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

Closed

Puzzle
Expired: 01/17/20 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 20,352
Categories: Design, Overall, Symmetry
Design a symmetric trimer, with 3 identical chains that assemble together! This puzzle includes a Secondary Structure Objective so that no more than 50% of residues may form helices. The H-bond Network Objective encourages players to bury satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see which residues count as core in the H-bond Networks.
Puzzle
Expired: 01/16/20 23:00:00
10 comments
Top Group: Anthropic Dreams
Top Player: fiendish_ghoul
Top Score: 11,561
Categories: Overall, Prediction
Fold this transposase protein from a CRISPR-Cas complex! CRISPR-Cas is a mixed complex of RNA and proteins, which work together to make a very precise cut in a cell's DNA. Scientists recently discovered a variant of CRISPR-Cas that coopts a new protein called a transposase. In addition to cutting DNA, the transposase also allows precise insertion of new material into a target DNA strand. This new variant could lead to more efficient gene editing with CRISPR-Cas! New cryoEM experiments have shed some light on the transposase structure, which was previously unknown.
Puzzle
Expired: 01/15/20 18:00:00
2 comments
Top Group: Go Science
Top Player: mirp
Top Score: 9,095
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small peptide is part of a larger protein that helps to regulate cell division, and is very important in early embryonic development. The protein is modeled here as in a reduced environment, so no disulfide bonds are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 01/10/20 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: grogar7
Top Score: 22,345
Categories: Design, Overall, Symmetry
Design a symmetric tetramer, with 4 identical chains that assemble together! The H-bond Network Objective encourages players to bury satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see which residues count as core in the H-bond Networks.
Puzzle
Expired: 01/09/20 23:00:00
3 comments
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 12,234
Categories: Design, Overall
This is the sixth puzzle in the poly-proline helix design series! The starting structure is an 80 reside protein with a 5 residue helix, and all residues are mutable. However we have also increased the reference weight of proline from 16.4 to 50.0 to incentivize keeping proline part of the final design. There were some designs from the previous puzzle that satisfied a good fraction of the oxygens and nitrogens on the helix backbone, and we hope to see that continue. Hydrogen bonds are visible by selecting 'Show advanced GUI' in General Options in the Menu tab, and then selecting 'Show bonds (loop)' and 'Show bondable atoms' in the View tab.
Puzzle
Expired: 01/08/20 18:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: grogar7
Top Score: 11,104
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein, isolated from the hookworm A. caninum, is an extremely potent anticoagulant. This protein contains ten cysteine residues that oxidize to form five disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 01/03/20 23:00:00
2 comments
Top Group: Anthropic Dreams
Top Player: grogar7
Top Score: 23,612
Categories: Design, Overall, Symmetry
Design a symmetric tetramer, with 4 identical chains that assemble together! The H-bond Network Objective encourages players to bury satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see which residues count as core in the H-bond Networks.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons