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Puzzle
Expires: 01/27/22 18:00:00
Top Group: Go Science
Top Player: SiberianHusky
Top Score: 10,318
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This is a portion of a troponin protein found in the skeletal muscle of turkeys. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expires: 01/26/22 23:00:00
1 comment
Top Group: Go Science
Top Player: akaaka
Top Score: 10,033
Categories: Design, Overall
Design a protein that can bind to the TGF-beta receptor! This puzzle enables AlphaFold predictions for your designed binder. Once you've designed a binder for the target, upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your binder chain only (i.e. in the unbound state, in the absence of the target). If you load this prediction, then Foldit will attempt to align the prediction with your solution (i.e. in the bound state, making an interface with the target). If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the binder interacts with the target.
Puzzle
Expires: 01/21/22 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 21,953
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains of 80 residues each! This puzzle enables AlphaFold predictions for the monomer subunit of your design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your monomer subunit only (i.e. in the unbound state, in the absence of other symmetric copies). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the monomer subunit interacts with symmetric copies.
Puzzle
Expires: 01/31/22 23:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 13,881
Categories:
This sandbox puzzle features a protein binder design by an anonymous player sgeldhof in Puzzle 2078: CD47 Binder Design: Round 5. The binder has a complementary shape for hydrophobics on the target surface, and perfectly satisfies buried polars. For more, check out Foldit Lab Report #28 on YouTube! This sandbox puzzle is non-competitive and will not award any points.

Closed

Puzzle
Expired: 01/20/22 18:00:00
3 comments
Top Group: Anthropic Dreams
Top Player: grogar7
Top Score: 9,322
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This is a trypsin inhibitor in pumpkins. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant. Players will NOT be able to load in any previous solutions for these puzzles.
Puzzle
Expired: 01/19/22 23:00:00
1 comment
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 15,580
Categories: Design, Overall
Design a binding pocket for the olivetolic acid ligand! This puzzle enables AlphaFold predictions for your binder design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your binder only (i.e. in the absence of the ligand). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments in the binding pocket where the ligand makes contact with your binder design.
Puzzle
Expired: 01/14/22 23:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 24,296
Categories: Design, Overall, Symmetry
Design a symmetric protein tetramer, with 4 identical chains of 90 residues each! This puzzle enables AlphaFold predictions for the monomer subunit of your design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your monomer subunit only (i.e. in the unbound state, in the absence of other symmetric copies). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the monomer subunit interacts with symmetric copies.
Puzzle
Expired: 01/13/22 18:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 11,199
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This saposin protein from pig serves as an activator for lipid-desolving enzymes. This protein contains six cysteines that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expired: 01/12/22 23:00:00
3 comments
Top Group: Contenders
Top Player: Cyberkashi
Top Score: 28,861
Categories: Overall, Small Molecule Design
Design a small molecule which can bind VHL! This is the tenth (and final!) in a series of puzzles using the small molecule design tools to design small molecule binders to the von Hippel-Lindau E3 ubiquitin ligase. We don't want you to modify the protein, but instead we'd like you to build new small molecules which fit into the VHL pocket. See the new "Inside the Pocket" and "Fun with Fragments!" tutorials to learn how to use the small molecule design tools.
Puzzle
Expired: 01/07/22 23:00:00
Top Group: Go Science
Top Player: jeff101
Top Score: 13,668
Categories: Design, Overall
Design a protein that can bind to CD47! This puzzle enables AlphaFold predictions for your designed binder. Once you've designed a binder for the target, upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your binder chain only (i.e. in the unbound state, in the absence of the target). If you load this prediction, then Foldit will attempt to align the prediction with your solution (i.e. in the bound state, making an interface with the target). If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the binder interacts with the target.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons