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Puzzle
Expires: 09/24/21 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: Enzyme
Top Score: 10,885
Categories: Design, Overall
Design a protein that can bind to the TGF-beta receptor! This puzzle enables AlphaFold predictions for your designed binder. Once you've designed a binder for the target, upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your binder chain only (i.e. in the unbound state, in the absence of the target). If you load this prediction, then Foldit will attempt to align the prediction with your solution (i.e. in the bound state, making an interface with the target). If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the binder interacts with the target.
Puzzle
Expires: 09/23/21 18:00:00
1 comment
Top Group: Gargleblasters
Top Player: Skippysk8s
Top Score: 10,438
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin, produced by the Mozambique spitting cobra, induces contracture in skeletal and cardiac muscle. This protein contains eight cysteine residues, which oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expires: 09/22/21 23:00:00
1 comment
Top Group: Go Science
Top Player: toshiue
Top Score: 21,367
Categories: Design, Overall, Symmetry
Design a symmetric protein tetramer, with 4 identical chains of 70 residues each! This puzzle enables AlphaFold predictions for the monomer subunit of your design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your monomer subunit only (i.e. in the unbound state, in the absence of other symmetric copies). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the monomer subunit interacts with symmetric copies.
Puzzle
Expires: 09/30/21 23:00:00
Top Group: Contenders
Top Player: spvincent
Top Score: 13,434
Categories:
This sandbox puzzle features four diverse designs created by spvincent and ichwilldiesennamen in Puzzle 2027. Reset the puzzle to cycle through the different starting structures, or load solutions from Puzzle 2027 to continue previous work. New solutions from this puzzle will be examined by Foldit scientists and outstanding designs may be highlighted as the next Design of the Month! For more, check out Foldit Lab Report #24 on YouTube! This sandbox puzzle is non-competitive and will not award any points.

Closed

Puzzle
Expired: 09/17/21 23:00:00
1 comment
Top Group: Go Science
Top Player: toshiue
Top Score: 13,531
Categories: Design, Overall
Design a protein that can bind to CD47! This puzzle enables AlphaFold predictions for your designed binder. Once you've designed a binder for the target, upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your binder chain only (i.e. in the unbound state, in the absence of the target). If you load this prediction, then Foldit will attempt to align the prediction with your solution (i.e. in the bound state, making an interface with the target). If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the binder interacts with the target.
Puzzle
Expired: 09/16/21 18:00:00
1 comment
Top Group: Gargleblasters
Top Player: Beany
Top Score: 10,735
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein, which inhibits muscle contraction in the absence of calcium ions, changes conformation in the presence of calcium to allow muscle contraction. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/15/21 23:00:00
3 comments
Top Group: Gargleblasters
Top Player: HuubR
Top Score: 22,637
Categories: Design, Overall, Symmetry
Design a symmetric protein tetramer, with 4 identical chains of 80 residues each! This puzzle enables AlphaFold predictions for the monomer subunit of your design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your monomer subunit only (i.e. in the unbound state, in the absence of other symmetric copies). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the monomer subunit interacts with symmetric copies.
Puzzle
Expired: 09/10/21 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: HuubR
Top Score: 14,046
Categories: Design, Overall
Design a protein that can bind to the IL-2 receptor (IL-2R)! This puzzle enables AlphaFold predictions for your designed binder. Once you've designed a binder for the target, upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your binder chain only (i.e. in the unbound state, in the absence of the target). If you load this prediction, then Foldit will attempt to align the prediction with your solution (i.e. in the bound state, making an interface with the target). If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the binder interacts with the target.
Puzzle
Expired: 09/09/21 18:00:00
3 comments
Top Group: Anthropic Dreams
Top Player: sallallami
Top Score: 10,477
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This pheromone protein is secreted by the protist E. raikovi to initiate conjugation, the exchange of genetic material between two cells. This protein contains ten cysteine residues that oxidize to form five disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/08/21 23:00:00
7 comments
Top Group: Go Science
Top Player: toshiue
Top Score: 20,091
Categories: Design, Overall, Symmetry
Design a symmetric protein tetramer, with 4 identical chains of 60 residues each! This puzzle enables AlphaFold predictions for the monomer subunit of your design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your monomer subunit only (i.e. in the unbound state, in the absence of other symmetric copies). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the monomer subunit interacts with symmetric copies.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons