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Puzzle
Expires: 12/04/20 23:00:00
3 comments
Top Group: Gargleblasters
Top Player: Enzyme
Top Score: 14,873
Categories: Design, Overall
Design a binder for the viral spike of MERS-CoV! This puzzle does not use the new Contact Surface Objective and is more similar to the previous Round 4 puzzle, except that the Metrics bonuses have been scaled down significantly. In this puzzle, the Metrics have a ramped bonus; as you improve DDG, SASA, and SC, you will get an increasing bonus until you reach the threshold of DDG < -40, SASA > 1500, and SC > 0.6, and then the bonus will be capped. Remember that Metrics are slow to compute and run in the background, so gameplay may be different from regular puzzles. See the blog for more info about Foldit Metrics.
Puzzle
Expires: 12/03/20 18:00:00
1 comment
Top Group: L'Alliance Francophone
Top Player: christioanchauvin
Top Score: 11,973
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. The function of this thermophilic protein is unknown, but it is unusual among intracellular proteins in that the native structure includes disulfide bonds. This protein contains six cysteine residues that are oxidized to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expires: 12/02/20 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: Enzyme
Top Score: 25,039
Categories: Design, Overall
This is the fourth puzzle in the designable linker series! We are providing parts of two of the best-known designed binders to the SARS-CoV-2 spike, and are challenging players to link them together with a rigid linker! The two helical bundles are the parts of the two binders. They are currently connected with a flexible alanine linker that needs to be redesigned. We have also included the parts of the actual spike that are within 15 angstroms of the termini of the binders, so you know what regions your binder has to avoid to prevent clashing. The big thing for puzzles like these is to have buried hydrophobics at the interface between the linker and the binder helices. Packing the linker against the helices can help it maintain its shape.
Puzzle
Expires: 11/30/20 23:00:00
Top Group: Italiani Al Lavoro
Top Player: g_b
Top Score: 20,460
Categories:
This sandbox puzzle features a symmetric trimer design by CharlieFortsConscience, from Puzzle 1900. It is difficult to form a well-shaped trimer interface with sheets, but this design has very few voids at the interface!. For more, check out Foldit Lab Report #14 on YouTube! This sandbox puzzle is non-competitive and will not award any points.

Closed

Puzzle
Expired: 11/27/20 23:00:00
13 comments
Top Group: Gargleblasters
Top Player: Enzyme
Top Score: 26,015
Categories:
Note: Due to strange behavior and frequent hangs, this puzzle has been reduced to zero points. Players should not feel compelled to play it for competitive reasons. However, the results of this puzzle have exceptional scientific value, so the puzzle will remain active for those who wish to keep working. Once we find and fix the bugs, we intend to repost the puzzle so that players may load previous work and continue competitive play.
Puzzle
Expired: 11/26/20 18:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 9,848
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This enzyme helps to regenerate a cofactor that is necessary for nucleic acid synthesis; the starting structure is a model produced by Rosetta. This protein contains only one cysteine, so no disulfide bonds are expected. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 11/25/20 23:00:00
5 comments
Top Group: Go Science
Top Player: toshiue
Top Score: 21,546
Categories: Design, Overall
Note: This puzzle replaces Puzzle 1918, which had some scoring problems. Unfortunately, players may not load solutions from the original Puzzle 1918.
Puzzle
Expired: 11/25/20 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: grogar7
Top Score: 0
Categories:
Note: This puzzle was closed early due to some scoring problems, and has been reposted as Puzzle 1918b. Players may not load solutions into the reposted puzzle.
Puzzle
Expired: 11/19/20 23:00:00
3 comments
Top Group: Gargleblasters
Top Player: Skippysk8s
Top Score: 17,621
Categories: Design, Overall
Note: This puzzle replaces Puzzle 1916, which revealed a bug in the Contact Surface metric. This puzzle lacks the Contact Surface metric, but players may load solutions from the original Puzzle 1916.
Puzzle
Expired: 11/19/20 23:00:00
7 comments
Top Group: Gargleblasters
Top Player: Enzyme
Top Score: 20,445
Categories:
Note: This puzzle was closed early due to a bug in the Contact Surface metric, and is reposted as Puzzle 1916b. Players may load solutions from this puzzle into the reposted version.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons