Puzzles Feed

Current

Puzzle
Expires: 07/28/18 23:00:00
1 comment
Top Group: Go Science
Top Player: NinjaGreg
Top Score: 13,496
Categories: Overall, Prediction
This puzzle is a little different from other prediction puzzles in Foldit. This protein is a dimer (i.e. two chains fold up and bind each other) that was designed in the Baker Lab. The design has two identical H-bond networks that span the interface between the two chains. In order to solve this puzzle, Foldit players will have to fold each of the two chains, bring them together, and arrange the interface to form the two H-bond networks. The secondary structure of the designed protein is marked on the starting structure. See if you can fold this protein and find the H-bond networks!
Puzzle
Expires: 07/27/18 04:00:00
1 comment
Top Group: Go Science
Top Player: ZeroLeak7
Top Score: 10,626
Categories: Overall, Prediction
This cow protein, found in epithelial cells of the intestine, binds calcium as it moves from the digestive tract into the blood. In this experimental puzzle you will have 128 moves at your disposal. Once you use them up, you can reset and try something else!
Puzzle
Expires: 08/30/18 23:00:00
Top Group: FoldIt@Netherlands
Top Player: JasperD
Top Score: 13,125
Categories: Beginner
This is a small symmetric trimer design puzzle. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together. Your changes will be reflected in the symmetric unit. Make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4. For players with fewer than 150 global points.
Puzzle
Expires: 07/31/18 23:00:00
Top Group: Go Science
Top Player: Hollinas
Top Score: 14,021
Categories: Design, Overall
Redesign the active site to bind aflatoxin! This puzzle is much like Round 9 of the Aflatoxin Challenge, but now players may insert up to 20 extra residues into the designable loops, at a cost of 20 points per residue. Strong constraints will keep aflatoxin from moving too far from its starting position, but we think the extra wiggle room will allow Foldit players to design an active site that binds the molecule more tightly. Parts of the scaffold protein have been trimmed to reduce the size of the puzzle, and we've upweighted ligand interactions by a factor of five. We'd like to see if Foldit players can design proteins that make more interactions with the ligand! See the blog for more details.
Puzzle
Expires: 07/23/18 17:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,888
Categories: Overall, Prediction
This is another potent neurotoxin produced by scorpions, similar to that found in Puzzle 1542b. This protein contains eight cysteine residues that oxidize to form four disulfide bonds. In this experimental puzzle you will have 256 moves at your disposal. Once you use them up, you can reset and try something else!
Puzzle
Expires: 08/23/18 23:00:00
Top Group: Stuyvesant Molecular Science 2017-18
Top Player: pako1609
Top Score: 10,282
Categories: Beginner
We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.
Puzzle
Expires: 08/16/18 23:00:00
Top Group: Void Crushers
Top Player: Amsterdamaged
Top Score: 15,804
Categories: Beginner
In electron density puzzles, we give you some experimental data to help you find the correct fold. This data takes the form of an electron density, and appears in game as a guide. You can adjust the guide visualization by going to [Actions]>[Electron Density]. For players with fewer than 150 global points.
Puzzle
Expires: 08/09/18 23:00:00
Top Group: Void Crushers
Top Player: hexidecimalhack
Top Score: 9,448
Categories: Beginner
We are giving you this Parabacteroides Distasonis protein as an extended chain. The native is shown as a guide on this puzzle, so try using everything you have learned in the Intro levels to match the native fold. Hints and details are posted in the puzzle comments. For players with fewer than 150 global points.
Puzzle
Expires: 08/02/18 23:00:00
Top Group: Void Crushers
Top Player: spdenne
Top Score: 9,090
Categories: Beginner
We are giving you this currently unsolved short protein as an extended chain. It has only 48 residues and we're posting it with no secondary structure predictions. For players with fewer than 150 global points.
Puzzle
Expires: 07/26/18 23:00:00
Top Group: FoldIt@Netherlands
Top Player: JasperD
Top Score: 9,100
Categories: Beginner
This small unsolved Arabidopsis protein only has 59 residues and negatively controls the biosynthesis of starch in plants and regulates leaf and seed composition. We are giving you 5 starts for this puzzle. Resetting the puzzle will cycle through these 5 Zhang server predictions. They are also in the Alignment Tool so you can use partial threading as well as an extended chain. For players with fewer than 150 global points.
Get Started: Download
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.7 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Search
Only search fold.it
Recommend Foldit
User login
Soloists
Evolvers
Groups
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons