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Puzzle
Expires: 11/22/18 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: phi16
Top Score: 20,910
Categories: Design, Overall
This symmetric design puzzle has C2 symmetry, with two symmetric chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). However, solutions may have no more than 50% of residues in helices. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Puzzle
Expires: 11/20/18 18:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: phi16
Top Score: 11,287
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein, isolated from the hookworm A. caninum, is an extremely potent anticoagulant. This protein contains ten cysteine residues that oxidize to form five disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expires: 11/27/18 14:00:00
17 comments
Top Group: Go Science
Top Player: fiendish_ghoul
Top Score: 18,253
Categories: Electron Density, Overall, Prediction
This protein is another part of the same protein complex with multiple subunits from Puzzle 1554 and Puzzle 1588, which has been the target of cryo-EM experiments. We are giving you an extended chain to start with, so good luck!
Puzzle
Expires: 11/21/18 23:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 13,396
Categories: Design, Overall
Note: This puzzle is much like Puzzle 1595, which had problems with shared solutions. Unfortunately, players will not be able to load in solutions from Puzzle 1595 or previous rounds of the Aflatoxin Challenge.

Closed

Puzzle
Expired: 11/13/18 18:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 9,902
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small domain is part of a larger protein that mediates interactions between other proteins in human development. This protein contains several cysteine residues, but we are modeling them in a reducing environment, so they should NOT form disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 11/12/18 23:00:00
7 comments
Top Group: freefolder
Top Player: ernest.chemist
Top Score: 21,273
Categories: Pilot, Small Molecule Design

The goal of this puzzle is to change the chemical structure of the ligand in the center of the protein to find better inhibitors of HIV protease. It's less about changing the protein to fit the ligand, and more about changing the ligand to fit the protein. Use the Ligand Design tool in the selection interface (or the "Ligand Design" mode in the original interface) to alter the chemical identity of the inhibitor.

Puzzle
Expired: 11/09/18 23:00:00
6 comments
Top Group: Contenders
Top Player: Mark-
Top Score: 13,282
Categories:
Note: Due to a bug in solution sharing and loading, this puzzle is worth zero points and will close early. We encourage players to play replacement puzzle Puzzle 1597 instead, although we will still analyze the solutions from this puzzle if players wish to keep working on their designs. Unfortunately players may not load solutions from this puzzle into the replacement Puzzle 1597.
Puzzle
Expired: 11/05/18 18:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 9,885
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This toxin, which is released by the sea anemone A. xanthogrammica, disrupts normal contraction of cardiac muscle in potential predators, and furthermore serves as a pheromone to signal danger to nearby anemones. This protein contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 11/02/18 23:00:00
6 comments
Top Group: Void Crushers
Top Player: Mike Cassidy
Top Score: 19,833
Categories:
Note: Due to exceptional performance issues, this puzzle has been made worth zero points. Players should not feel compelled to play this puzzle to remain competitive on the leaderboards. However, if you are able to play this puzzle without issue, we'll still analyze any solutions.
Puzzle
Expired: 11/04/18 23:00:00
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 12,050
Categories: Design, Overall
Note: This puzzle replaces Puzzle 1590b, which had some intermittent scoring problems. Players may load in solutions saved from Puzzle 1590b.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons