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Puzzle
Expires: 09/25/20 18:00:00
Top Group: Go Science
Top Player: mirp
Top Score: 11,525
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein helps to regulate the human immune response, and the starting structure is a Rosetta model. The protein is modeled here in the reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.
Puzzle
Expires: 09/24/20 23:00:00
1 comment
Top Group: Go Science
Top Player: nspc
Top Score: 14,455
Categories:
This is a non-competitive version of Puzzle 1892, with binder metric Objectives so that players can check the DDG, SASA, and shape complementarity of their Puzzle 1889 solutions. The binder metric Objectives do not award any bonus or penalties. Players may share solutions freely between this puzzle and the original Puzzle 1892.
Puzzle
Expires: 09/24/20 23:00:00
6 comments
Top Group: Gargleblasters
Top Player: Joanna_H
Top Score: 14,810
Categories: Design, Overall
Design a binder against coronavirus! The new metrics have been left out to preserve regular recipe performance, but other Objectives are still in effect. Remember, if your designed protein creates Buried Unsats, then it will be less likely to fold and bind to the coronavirus target. (Note that this target protein includes 8 buried unsats that players may be unable to fix.) See the blog for more details about buried unsats, and for helpful tips to make a successful protein binder! Players may not load solutions from previous puzzles.
Puzzle
Expires: 09/23/20 23:00:00
3 comments
Top Group: Go Science
Top Player: dcrwheeler
Top Score: 22,826
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains that assemble together! Note the Interaction Energy Objective, which will penalize poorly-scoring large residues that can lead to unwanted protein aggregation. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expires: 09/30/20 23:00:00
6 comments
Top Group: Anthropic Dreams
Top Player: phi16
Top Score: 13,691
Categories:
Note: This replaces the original LCB1 puzzle, which had some incorrect settings for Core Exists, Ideal Loops, and SS Design Objectives.

Closed

Puzzle
Expired: 09/18/20 18:00:00
3 comments
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 9,957
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small protein, from the venom of the saw-scaled viper, interferes with the cellular adhesion machinery that allows blood clotting. This protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 09/17/20 23:00:00
1 comment
Top Group: Gargleblasters
Top Player: OWM3
Top Score: 11,922
Categories:
This is a non-competitive version of Puzzle 1889, with binder metric Objectives so that players can check the DDG, SASA, and shape complementarity of their Puzzle 1889 solutions. The binder metric Objectives do not award any bonus or penalties. Players may share solutions freely between this puzzle and the original Puzzle 1889.
Puzzle
Expired: 09/17/20 23:00:00
5 comments
Top Group: Gargleblasters
Top Player: Jpilkington
Top Score: 11,986
Categories: Design, Overall
Design an anti-inflammatory protein for COVID-19! We'd like players to keep focusing on making closely-packed interfaces with no extra Buried Unsats. This puzzle prohibits SER and THR in helices, which may make it harder to satisfy BUNS, but should help the helices to fold correctly. Remember, if your designed protein creates Buried Unsats, then it will be less likely to fold and bind to the target. (Note that this target protein includes 15 buried unsats that players may be unable to fix.) See the blog for more details about buried unsats, and for helpful tips to make a successful protein binder! Players will be unable to load solutions from previous puzzles.
Puzzle
Expired: 09/16/20 23:00:00
3 comments
Top Group: Contenders
Top Player: CharlieFortsCon...
Top Score: 20,574
Categories: Design, Overall, Symmetry
Design a symmetric protein trimer, with 3 identical chains that assemble together! Note the Interaction Energy Objective, which will penalize poorly-scoring large residues that can lead to unwanted protein aggregation. The H-bond Network Objective encourages players to build buried, satisfied H-bond networks at the interface between symmetric chains. H-bond networks are a great way to introduce polar residues at the interface, but it's important that all of the bondable atoms make hydrogen bonds! We've also adjusted the H-bond Network Objective so that poor-scoring H-bonds may not contribute to networks; poor-scoring H-bonds will be displayed in red. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. In this puzzle, there are no limits on the Complex Core, but we've included the Complex Core objective so players can see the core residues that can be incorporated into H-bond Networks.
Puzzle
Expired: 09/11/20 18:00:00
Top Group: Go Science
Top Player: mirp
Top Score: 11,108
Categories: Overall, Prediction
CASP14 has released this refinement target without any accuracy estimates, so we're unsure how well the starting structure matches the native structure. Look for better scoring folds to find the true native structure!
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons