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Puzzle
Expires: 06/18/21 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Crossed Sticks
Top Score: 13,484
Categories: Design, Overall
Note: This puzzle replaces the original Puzzle 2005 which used a mis-calibrated score function. Players may load in solutions from the original Puzzle 2005.
Puzzle
Expires: 06/17/21 18:00:00
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 10,494
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This DNA-binding domain is part of a bacterial integrase protein, which facilitates the insertion of new DNA into the bacterial chromosome. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expires: 06/16/21 23:00:00
1 comment
Top Group: Beta Folders
Top Player: LociOiling
Top Score: 31,046
Categories: Design, Overall, Symmetry
Design a D2 symmetric protein tetramer, with 4 identical chains of 90 residues each! Unlike the cyclical C4 symmetry that we are used to, the proteins in this puzzle will come together as a "dimer of dimers" with D2 symmetry. This puzzle has no H-Bond Network Objective, but there is "Core Limit: Complex" objective meant to regulate the size of the interface between symmetric chains. An interface that is too large, with too many orange hydrophobics, can prevent the individual subunits from folding properly; on the other hand, an interface that is too small does not provide enough interactions for assembly The "Core Limit: Complex" objective will incur penalties if there are too many, or too few buried residues in the total assembly. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. See the puzzle comments for more Objective details.
Puzzle
Expires: 06/30/21 23:00:00
Top Group: Anthropic Dreams
Top Player: phi16
Top Score: 10,425
Categories:
This sandbox puzzle features a binder design for the TGF Receptor, created by toshiue in Puzzle 1985. This design uses polar sidechains to make H-bonds with the target, creating a fully satisfied interface with zero BUNS! For more, check out Foldit Lab Report #21 on YouTube! This sandbox puzzle is non-competitive and will not award any points.

Closed

Puzzle
Expired: 06/18/21 23:00:00
3 comments
Top Group: Anthropic Dreams
Top Player: stomjoh
Top Score: 0
Categories:
Note: This puzzle was closed early due to scoring problems and reposted as Puzzle 2005b. Players may save any work from this puzzle and load it into the reposted Puzzle 2005b.
Puzzle
Expired: 06/11/21 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,707
Categories: Design, Overall
Design a protein that can bind to the TGF-beta receptor! We have been seeing excellent designs from the previous puzzles, so this puzzle is set up just the same. Try to max out the Contact Surface Objective by using sidechains that pack closely against the target binding site!
Puzzle
Expired: 06/10/21 18:00:00
1 comment
Top Group: Beta Folders
Top Player: sallallami
Top Score: 10,253
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein helps to transfer electrons between substrates in bacteria. The protein is modeled here in reducing conditions, and no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 06/09/21 23:00:00
3 comments
Top Group: Go Science
Top Player: silent gene
Top Score: 26,393
Categories: Design, Overall, Symmetry
Design a D2 symmetric protein tetramer, with 4 identical chains of 70 residues each! Unlike the cyclical C4 symmetry that we are used to, the proteins in this puzzle will come together as a "dimer of dimers" with D2 symmetry. This puzzle has no H-Bond Network Objective, but there is "Core Limit: Complex" objective meant to regulate the size of the interface between symmetric chains. An interface that is too large, with too many orange hydrophobics, can prevent the individual subunits from folding properly; on the other hand, an interface that is too small does not provide enough interactions for assembly The "Core Limit: Complex" objective will incur penalties if there are too many, or too few buried residues in the total assembly. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. See the puzzle comments for more Objective details.
Puzzle
Expired: 06/04/21 23:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,786
Categories: Design, Overall
Design a protein to bind to the Tie2 receptor! We saw lots of great designs in the previous Round 3 puzzle, so this puzzle is set up just the same. Try to max out the Contact Surface Objective by using sidechains that pack closely against the target binding site!
Puzzle
Expired: 06/02/21 23:00:00
4 comments
Top Group: Go Science
Top Player: dcrwheeler
Top Score: 28,874
Categories: Design, Overall, Symmetry
Design a D2 symmetric protein tetramer, with 4 identical chains of 80 residues each! Unlike the cyclical C4 symmetry that we are used to, the proteins in this puzzle will come together as a "dimer of dimers" with D2 symmetry. This puzzle has no H-Bond Network Objective, but there is "Core Limit: Complex" objective meant to limit the size of the interface between symmetric chains. An interface that is too large, with too many orange hydrophobics, can prevent the individual subunits from folding properly. The "Core Limit: Complex" objective will incur penalties if there are too many buried residues in the total assembly. This puzzle uses the Buried Unsats Objective, with a large penalty for buried polar atoms that can't make H-bonds. See the puzzle comments for more Objective details.
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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons