Puzzles Feed

Current

Puzzle
Expires: 12/09/21 18:00:00
Top Group: Go Science
Top Player: xythus
Top Score: 10,517
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. In the struggle for limited resources, some strains of the bacteria E. coli produce a potent toxin to fight off competing strains. This small immunity protein protects the aggressor E. coli from falling victim to its own toxin. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been, and to provide newer players with easier puzzles that are still scientifically relevant.
Puzzle
Expires: 12/08/21 23:00:00
1 comment
Top Group: Contenders
Top Player: Aubade01
Top Score: 26,027
Categories: Overall, Small Molecule Design
Note: This is a repost of Puzzle 2074, but without the problematic 'Preserve Structure' objective. Solutions from the previous puzzles can be loaded into this one.
Puzzle
Expires: 12/31/21 23:00:00
Top Group: Go Science
Top Player: Aubade01
Top Score: 20,038
Categories:
This sandbox puzzle features a small molecule design by an anonymous player in Puzzle 2062: VHL Ligand Design: Round 2. The central structure of this molecule has been modified with an aromatic ring system, which backs up a key hydroxyl that makes two critical H-bonds to the target protein. Keep an eye on the cLogP and TPSA Objectives to strike a balance between the hydrophobic and polar atoms in your small molecule designs! For more, check out Foldit Lab Report #27 on YouTube! This sandbox puzzle is non-competitive and will not award any points.
Puzzle
Expires: 12/03/21 23:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 22,913
Categories: Design, Overall, Symmetry
Design a symmetric protein tetramer, with 4 identical chains of 80 residues each! This puzzle enables AlphaFold predictions for the monomer subunit of your design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your monomer subunit only (i.e. in the unbound state, in the absence of other symmetric copies). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the monomer subunit interacts with symmetric copies.

Closed

Puzzle
Expired: 12/02/21 18:00:00
1 comment
Top Group: Anthropic Dreams
Top Player: Galaxie
Top Score: 10,488
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This protein is found on the surface of bacteriophage fd, a virus that infects E. coli. It is responsible for penetrating the cell membrane of the host bacteria, allowing virus to enter the cell. This protein contains four cysteines that oxidize to form two disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been, and to provide newer players with easier puzzles that are still scientifically relevant.
Puzzle
Expired: 12/01/21 23:00:00
8 comments
Top Group: Contenders
Top Player: Bletchley Park
Top Score: 164,744
Categories:
Due to issues with objectives, this puzzle has been closed early and is now worth zero competition points. It has been reposted as Puzzle 2074b. All saved solutions from this puzzle can be loaded into the reposted puzzle.
Puzzle
Expired: 11/26/21 23:00:00
1 comment
Top Group: Go Science
Top Player: Bruno Kestemont
Top Score: 15,589
Categories: Design, Overall
Design a binding pocket for the olivetolic acid ligand! This puzzle enables AlphaFold predictions for your binder design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your binder only (i.e. in the absence of the ligand). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments in the binding pocket where the ligand makes contact with your binder design.
Puzzle
Expired: 11/25/21 18:00:00
1 comment
Top Group: Contenders
Top Player: guineapig
Top Score: 9,804
Categories: Overall, Prediction
This is a throwback puzzle to the early days of Foldit. This small disulfide-rich protein is produced by the moth H. virescens as a defense against certain bacterial and fungal infections. This protein contains six cysteines that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
Puzzle
Expired: 11/24/21 23:00:00
1 comment
Top Group: Go Science
Top Player: Aubade01
Top Score: 22,291
Categories: Overall, Small Molecule Design
Design a small molecule which can bind VHL! This is the third in a series of puzzles using the small molecule design tools to design small molecule binders to the von Hippel-Lindau E3 ubiquitin ligase. We don't want you to modify the protein, but instead we'd like you to build new small molecules which fit into the VHL pocket. See the new "Inside the Pocket" and "Fun with Fragments!" tutorials to learn how to use the small molecule design tools.
Puzzle
Expired: 11/19/21 23:00:00
1 comment
Top Group: Go Science
Top Player: toshiue
Top Score: 20,039
Categories: Overall, Symmetry
Design a symmetric protein tetramer, with 4 identical chains of 60 residues each! This puzzle enables AlphaFold predictions for the monomer subunit of your design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your monomer subunit only (i.e. in the unbound state, in the absence of other symmetric copies). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the monomer subunit interacts with symmetric copies.
User login
Download links:
  Windows    OSX    Linux  
Windows
(7/8/10)
OSX
(10.12 or later)
Linux
(64-bit)

Are you new to Foldit? Click here.

Are you a student? Click here.

Are you an educator? Click here.
Social Media


Search
Only search fold.it
Other Games: Mozak
Recommend Foldit
Topics
Top New Users
Sitemap

Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons