puzzle picture
972: 80 Residue Monomer Design: Pro Loops
Status: Closed

Summary

Name: 972: 80 Residue Monomer Design: Pro Loops
Status: Closed
Created: 08/21/2014
Points: 100
Expired: 08/28/2014 - 23:00
Difficulty: Intermediate
Description: In this design puzzle, we're encouraging players to incorporate PRO residues in the loops of their designs, so PRO residues will score more favorably than normal. Players will receive a 500 point bonus from the Secondary Structure filter if fewer than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices. The Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

Top Groups

RankGroupScorePoints
1L'Alliance Francophone10,409100
2Anthropic Dreams10,36183
3Beta Folders10,28568
4 An Art That's Smart10,23555
5Contenders10,06844

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Comments

spmm's picture
User offline. Last seen 44 weeks 6 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
arginine bonus?

:P

wisky's picture
User offline. Last seen 12 weeks 5 days ago. Offline
Joined: 07/13/2011
BIGGAR!

Would very much like to see a couple design puzzles along the road with 120 or even 150 residues :) I think it would give a lot more room for interesting designs like beta barrels and the like. Not saying every design from here on out should be large like that, but it would be cool to have a couple of them :)

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons