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969: 75 Residue Monomer Design: Folded Sheets
Status: Closed


Name: 969: 75 Residue Monomer Design: Folded Sheets
Status: Closed
Created: 08/14/2014
Points: 100
Expired: 08/21/2014 - 23:00
Difficulty: Intermediate
Description: In this design puzzle, players will receive a 500 point bonus from the Secondary Structure filter if at least 50% of residues are in sheets; penalties are incurred if fewer than 50% of residues form sheets. There are 3 additional filters: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

Top Groups

1Beta Folders10,181100
2Go Science10,07283
3Anthropic Dreams10,00669
5L'Alliance Francophone9,87345

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Joined: 12/06/2008
Groups: Contenders
Sheet scoring doesn't work.

I have thirty-eight segments in the sheet configuration, which is more than fifty percent, yet I am still penalized thousands of points. Please review your scoring algorithms.

Joined: 10/30/2012
Groups: Beta Folders
they have to be in contact

they have to be in contact for the scoring function to work

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons