puzzle picture
955: 70 Residue Monomer Design
Status: Closed


Name: 955: 70 Residue Monomer Design
Status: Closed
Created: 07/31/2014
Points: 100
Expired: 08/06/2014 - 23:00
Difficulty: Intermediate
Description: This design puzzle uses a Secondary Structure filter similar to that of Puzzle 937. Players will receive a 500 point bonus if fewer than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices. There are 3 additional filters: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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spmm's picture
User offline. Last seen 7 weeks 4 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
less flexible than the last one

imo this puzzle seems to be less flexible than the last one which was only a bit shorter. Less fun to play.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons