puzzle picture
937: 65 Residue Monomer Design
Status: Closed


Name: 937: 65 Residue Monomer Design
Status: Closed
Created: 07/10/2014
Points: 100
Expired: 07/17/2014 - 23:00
Difficulty: Intermediate
Description: This design puzzle introduces a new filter! The Secondary Structure filter counts the number of residues in helices or sheets by recognizing hydrogen-bonding patterns. Players will receive a 500 point bonus if fewer than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices. There are 3 additional filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 20% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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Joined: 12/06/2008
Groups: Contenders
The FoldIt gods have finally listened!

After years of devoted sacrifice on the Altar of the Aminos, the FoldIt gods have finally heard my prayer!

The megahelix was an evil, evil construction, spawned from the depths of the abyss, created to supplant the folding scores of realistic designs garnered by the Faithful and send them to the bottom of the top fifty.

But no more! From the heavens came The Secondary Structure Filter, and it divinely kicked the megahelix back into the bowels of Hell, where it belongs.

I bow in honor and reverence to the new Folding Design World Order.

wisky's picture
User offline. Last seen 1 year 5 weeks ago. Offline
Joined: 07/13/2011
O frabjous day! Callooh! Callay!

One, two! One, two! and through and through
The vorpal blade went snicker-snack!
He left it dead, and with its head
He went galumphing back.

"And hast thou slain the Jabberwock?
Come to my arms, my beamish boy!
O frabjous day! Callooh! Callay!"
He chortled in his joy.

'Twas brillig, and the slithy toves
Did gyre and gimble in the wabe;
All mimsy were the borogoves,
And the mome raths outgrabe.

Joined: 04/11/2013
Megahelix thou hast been High

Megahelix thou hast been
High scoring and obscene
By folders thou wast deemed
No friend but a fiend

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons