puzzle picture
918: Extra Credit CASP11 T0804: WeFold
Status: Closed

Summary

Name: 918: Extra Credit CASP11 T0804: WeFold
Status: Closed
Created: 06/18/2014
Points: 10
Expired: 06/23/2014 - 12:00
Difficulty: Advanced
Description: Our WeFold collaborators are asking for your help! They have identified a server model that shows promise, but is clearly an unproteinlike prediction. Because this CASP11 target is so large, our WeFold collaborators tried to manually fix this server prediction on their own... but they are certain that you can do much better than them! We are giving you both the ugly server model and the manual WeFold prediction (along with the Alignment Tool). Since this target is too big to be a regular Foldit puzzle, we are posting it as an 'Extra Credit' CASP11 puzzle. It is only worth 10 points with no categories. More details in the puzzle comments.
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Comments

beta_helix's picture
User offline. Last seen 3 hours 25 min ago. Offline
Joined: 05/09/2008
Groups: None
More details:

We had asked for your feedback about whether we should participate in these larger CASP11 targets:
http://fold.it/portal/node/997715#comment-27760

We have since ignored the bigger CASP11 puzzles, but our WeFold collaborators insisted on this target... so we wanted to give you an opportunity to play this puzzle if you want to without the feeling that you have to play it or else you'll be missing out on points/categories.

This is purely extra credit, so have fun with it if you like, and no regrets if this puzzle is too slow for you!

beta_helix's picture
User offline. Last seen 3 hours 25 min ago. Offline
Joined: 05/09/2008
Groups: None
Secondary structure predictions:

Here is the sequence logo predicted by the SAM server:

NOTE: Numbering is off as the first 8 residues were trimmed by WeFold

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

Note that these secondary structure predictions are not necessarily present in the models that have been provided in the puzzle.

spmm's picture
User offline. Last seen 43 weeks 1 day ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
ten points?

so do we get the 10 points if we actually make a effort or do we have to get rank 1 to get the 10 points? (I really am happy to play about with this nice beautiful big one)
erm...

Joined: 05/29/2012
Groups: None
You are awesome!

Dear Foldit players, on behalf of the WeFolders who insisted on this target I want to thank you for the great work you do. If very seasoned biologists think that you can do a better job than they can at improving the models then you must be really awesome! :) Keep up the great work!
Silvia

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