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919: 70 Residue Monomer Design: Strand Constraints
Status: Closed


Name: 919: 70 Residue Monomer Design: Strand Constraints
Status: Closed
Created: 06/16/2014
Points: 100
Expired: 06/24/2014 - 23:00
Difficulty: Intermediate
Description: This is a single-chain design puzzle very similar to Puzzle 887, with four residues pre-folded into beta-strand conformation. These residues are somewhat flexible, but there are strong constraints to keep them close to beta-strand conformation. There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 25% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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