The puzzle filters "not enough residues in the core" or "fragment Score" could be explained better.
Clicking on "show all" lights up the entire structure in red. But what is the problem? Is the vague concept of the "core" not sufficiently tightly packed, so I need to compress that structure (never helps) or do I need to mutate all sidechains to something better or what?
It's like saying one has a specific problem, and then outlining the entire general structure to be included in this specific problem.
Potential solutions to solve the filters would be nice.
Or a better functionality of the "show all" function.
also on this topic, though specific to an older puzzle: