puzzle picture
903: Brain Cancer-Related Phosphorylated Id2
Status: Closed

Summary

Name: 903: Brain Cancer-Related Phosphorylated Id2
Status: Closed
Created: 05/28/2014
Points: 100
Expired: 06/05/2014 - 23:00
Difficulty: Intermediate
Description: Researchers at Dartmouth College are trying to determine the structure of the Id2 protein, and have asked for Foldit's help! Id2 is a regulatory protein that has been implicated in some brain cancers. The N- and C-terminal tails of Id2 are very important for the protein's function, but the structure of these regions is unknown. Help determine the structure of this Id2's tail regions in its symmetric dimer form! The central helices of this protein are held in place by constraints, although some slight movement is allowed. Also, note that the serine at position 14 has a negatively charged phosphate group attached. Read the blogpost for more info!
Categories: Overall, Prediction, Symmetry

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Comments

wisky's picture
User offline. Last seen 19 weeks 4 days ago. Offline
Joined: 07/13/2011
Large protein!

CASP is upon us, and we get a large symmetry puzzle!

Perhaps a a few more days are warranted for this puzzle? :)

spvincent's picture
User offline. Last seen 9 hours 33 min ago. Offline
Joined: 12/07/2007
Groups: Contenders
SS predictions

Are there going to be any Secondary Structure predictions for this puzzle?

beta_helix's picture
User offline. Last seen 14 hours 7 min ago. Offline
Joined: 05/09/2008
Groups: None
Secondary structure predictions:

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

wisky's picture
User offline. Last seen 19 weeks 4 days ago. Offline
Joined: 07/13/2011
lol

Not really from what I've seen. I've tried jpred and phyre and it's coming up with 60+ residues of loops

beta_helix's picture
User offline. Last seen 14 hours 7 min ago. Offline
Joined: 05/09/2008
Groups: None
We can add more days to this puzzle...

Perhaps after the Scientist Chat we can decide if we want to add more days to this puzzle, or post a different round of it.

I'm running the SAM predictions right now, feel free to check them out while they are running:
http://compbio.soe.ucsc.edu/SAM_T08/results/target08-query-1401418399-9829/summary.html

This is the PDB page of ID2 (with the tails missing):
www.rcsb.org/pdb/explore/explore.do?structureId=4AYA

Joined: 10/30/2012
Groups: Beta Folders
we don't need extra days,

we don't need extra days, lets quit while I am ahead

Joined: 09/21/2011
Groups: Void Crushers
More days were not needed to

More days were not needed to catch you. ;-)

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