puzzle picture
898b: 75 Residue Monomer Design: Weak Helices
Status: Closed

Summary

Name: 898b: 75 Residue Monomer Design: Weak Helices
Status: Closed
Created: 05/23/2014
Points: 100
Expired: 05/28/2014 - 23:00
Difficulty: Intermediate
Description: NOTE: This is a repost of Puzzle 898, with the Fragment Filter removed.

This is a design puzzle with 75 residues and is very similar to previous design puzzles, except that helices should not score as well as they normally do. Try some new designs and see how they compete with handicapped helices! There are 2 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well, and the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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Comments

Joined: 10/30/2012
Groups: Beta Folders
I'm guessing you did not mean

I'm guessing you did not mean to award points for 898

spmm's picture
User offline. Last seen 41 weeks 3 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
wiggle power?

I am not finding any difference between low and medium wiggle power on this one.

Joined: 10/30/2012
Groups: Beta Folders
same here very little

same here very little difference

Joined: 10/30/2012
Groups: Beta Folders
constraints still need work,

constraints still need work, had some computer issues, so was not able to fully work the sheet array's. you could just set some rules, the folds must contain 3-5 elements 2 of which must be sheets.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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