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898: 75 Residue Monomer Design: Weak Helices
Status: Closed

Summary

Name: 898: 75 Residue Monomer Design: Weak Helices
Status: Closed
Created: 05/21/2014
Points: 0
Expired: 05/28/2014 - 23:00
Difficulty: Intermediate
Description: This is a design puzzle with 75 residues and is very similar to previous design puzzles, except that helices should not score as well as they normally do. Try some new designs and see how they compete with handicapped helices! There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!
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Comments

Joined: 10/30/2012
Groups: Beta Folders
not working, 20 min triple

not working, 20 min triple helix out scores a 2 hour sheet array

problem seems to be in fragment score, seems to be very difficult

to get the loops on the ends of the sheets to score.

bkoep's picture
User offline. Last seen 2 days 11 hours ago. Offline
Joined: 11/15/2012
Groups: None
Puzzle reposted

Thanks for the feedback retiredmichael! We've been wondering if the Fragment Filter has been problematic for different types of structures.

This puzzle has been reposted without the fragment filter here:
http://fold.it/portal/node/997791

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons