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898: 75 Residue Monomer Design: Weak Helices
Status: Closed
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Summary
| Name: |
898: 75 Residue Monomer Design: Weak Helices |
| Status: |
Closed |
| Created: |
05/21/2014 |
| Points: |
0 |
| Expired: |
05/28/2014 - 23:00 |
| Difficulty: |
Intermediate |
| Description: |
This is a design puzzle with 75 residues and is very similar to previous design puzzles, except that helices should not score as well as they normally do. Try some new designs and see how they compete with handicapped helices! There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions! |
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Comments
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not working, 20 min triple helix out scores a 2 hour sheet array
problem seems to be in fragment score, seems to be very difficult
to get the loops on the ends of the sheets to score.