puzzle picture
891: 80 Residue Monomer Design: Hairpinned
Status: Closed


Name: 891: 80 Residue Monomer Design: Hairpinned
Status: Closed
Created: 05/12/2014
Points: 100
Expired: 05/19/2014 - 23:00
Difficulty: Intermediate
Description: This is a single-chain design puzzle with 80 residues, and eight of the residues are pre-folded into a beta-hairpin. These residues are somewhat flexible, but there are strong constraints to keep them close to beta-hairpin conformation. There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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