puzzle picture
884b: 74 Residue Ebola Binder Design
Status: Closed

Summary

Name: 884b: 74 Residue Ebola Binder Design
Status: Closed
Created: 05/02/2014
Points: 150
Expired: 05/08/2014 - 23:00
Difficulty: Intermediate
Description: NOTE: This puzzle replaces Puzzle 884, which had scoring and filter calibration issues. Players may load in solutions from the originally posted puzzle.

This is a design puzzle similar to Puzzle 879—now with 74 residues—near the interface of a target glycoprotein from the Ebola virus. At the binding site of the Ebola protein, there is already a helix designed by scientists in the Baker Lab, but the helix will not fold up by itself! Build a scaffold around the starting design that will fold up properly and stabilize the binding helix! There are strong constraints to keep the binding helix in place, and you may not mutate residues at the interface. You may not add additional residues to the design, but you may delete residues from one end of the design and reinsert them at the other end. This puzzle includes a Residue IE Score filter and a Core Existence filter, and High Wiggle Power has been disabled. Remember to share your favorite designs using the Share with Scientist tool, even if those are not your best-scoring solutions!
Categories: Design, Overall

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Comments

bkoep's picture
User offline. Last seen 3 hours 38 min ago. Offline
Joined: 11/15/2012
Groups: None
Repost of 884

This puzzle should score have a more reasonable Core Exists filter threshold, and should score much higher in general than the original puzzle.

Joined: 09/21/2011
Groups: Void Crushers
Colouring of segments

If we are to get more Ebola puzzle, please make it so that the colouring of segments is only done to the segmentscores of the part we can influence (segments 186 and higher on this one).
Because of segments inside Ebola that score very badly we are not able to indentify bad scoring segment by visual means.

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons