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884: 74 Residue Ebola Binder Design
Status: Closed

Evolvers



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wisky's picture
User offline. Last seen 1 year 41 weeks ago. Offline
Joined: 07/13/2011
Core exists filter

Core exists filter appears to be taking into account residues from the ebola protein. The highest I was able to get it to with my current design was -480.

Joined: 10/30/2012
Groups: Beta Folders
is it just me or is this kind

is it just me or is this kind of slow and stiff

spmm's picture
User offline. Last seen 2 weeks 3 days ago. Offline
Joined: 08/05/2010
Groups: Void Crushers
2 dumb questions

The 104 - 106 segments - do we need to keep away from them because there is actually something there?

Seg 1 - serine - is that going to be connected to something else so needs room to do that?
thanks

Joined: 09/21/2011
Groups: Void Crushers
Score issues

1. The ebola part of the score is so negative that normal scoring and seeing how far pointswise you are on the scoring ladder is not possible as long as the total score is negative.
This should be corrected.
2. The filters should only work on the design part of the puzzle, not on the Ebola part. (would probably also speed up the puzzle).
3. As a consequence of 1 scripts that cant cope with negative scores or change behavior depending on the score don't work correctly.
(TIP for my DRW users: use More options and disable skip fuze and replace qstab)

bkoep's picture
User offline. Last seen 15 hours 8 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Puzzle closed

This puzzle has been closed and reposted with relaxed requirements for the Core Exists filter and raised baseline score:

http://fold.it/portal/node/997612

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, Boehringer Ingelheim, RosettaCommons