|Opened on:||Wednesday, March 12, 2014 - 02:59|
|Last modified:||Friday, March 14, 2014 - 22:17|
854 has been the most frustrating and pointless puzzle I have ever played. I never got out of the hand work stage, because every single small change I made, to a protein with no bad fragments, resulted in wiggle dropping several hundred points on the fragment filter. No bad fragments, tweak a sheet, still no bad fragments, shake and wiggle, wiggle creates 6 bad fragments. Same with rebuilds. Same with mutates. Over and over and over. The score function completely failed to give any feedback about what changes were making the protein better or worse, because the score changes were always swamped by the fragment pitfalls. The folding landscape that is supposed to be a funnel with local minima turned out to be all holes and no path between them. I knew my fold would not be a prize winner (it was not all helices, for starters), but if the score can't give any feedback at all on better vs. worse, there is no way to make progress.