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856: Trimer Interface Redesign: Round 3
Status: Closed

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wisky's picture
User offline. Last seen 1 week 6 days ago. Offline
Joined: 07/13/2011
Just wondering

Just wondering how you guys went about "increasing tolerance for buried polar residues." Does this have something to with the "hiding" subscore for polar residues?

bkoep's picture
User offline. Last seen 15 hours 1 min ago. Offline
Joined: 11/15/2012
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Yes

There's a score term (represented by the 'Hiding' subscore) in these puzzles that inflicts a penalty when a polar residue is in close proximity to many other residues (i.e. in the core of the protein).

This relative weight of this score term is reduced in each iteration of the puzzle.

wisky's picture
User offline. Last seen 1 week 6 days ago. Offline
Joined: 07/13/2011
Thanks!

Thanks for the response, bkoep :D

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