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856: Trimer Interface Redesign: Round 3
Status: Closed

Summary

Name: 856: Trimer Interface Redesign: Round 3
Status: Closed
Created: 03/07/2014
Points: 100
Expired: 03/10/2014 - 23:00
Difficulty: Intermediate
Description: This is the third round in a series of interface redesign puzzles with increasing tolerance for buried blue, polar residues. Try to redesign a more polar interface between the symmetric subunits of this protein! This symmetric trimer was originally designed by Museka in Puzzle 742. See Puzzle 851 for more information. Due to some bugs apparent in previous rounds of this puzzle, players will NOT be able to load in solutions from Puzzles 851 or 852.
Categories: Design, Overall, Symmetry

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Comments

Sat, 03/08/2014 - 01:56
#1
wisky 79 238
wisky's picture
User offline. Last seen 9 weeks 2 days ago. Offline
Joined: 07/13/2011
Groups: Anthropic Dreams
Just wondering

Just wondering how you guys went about "increasing tolerance for buried polar residues." Does this have something to with the "hiding" subscore for polar residues?

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Mon, 03/10/2014 - 03:11
#2
 bkoep 79 500
bkoep's picture
User offline. Last seen 1 hour 49 min ago. Offline
Joined: 11/15/2012
Groups: None
Yes

There's a score term (represented by the 'Hiding' subscore) in these puzzles that inflicts a penalty when a polar residue is in close proximity to many other residues (i.e. in the core of the protein).

This relative weight of this score term is reduced in each iteration of the puzzle.

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Tue, 03/11/2014 - 02:17
#3
wisky 79 238
wisky's picture
User offline. Last seen 9 weeks 2 days ago. Offline
Joined: 07/13/2011
Groups: Anthropic Dreams
Thanks!

Thanks for the response, bkoep :D

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
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