puzzle picture
851: Trimer Interface Redesign: Round 1
Status: Closed

Summary

Name: 851: Trimer Interface Redesign: Round 1
Status: Closed
Created: 02/27/2014
Points: 100
Expired: 03/03/2014 - 23:00
Difficulty: Intermediate
Description: This is a symmetric trimer that was originally designed by Museka in Puzzle 742. We'd like you to try to redesign the interface between the subunits to include a couple hydrogen bonds and blue, polar contacts amongst all the orange hydrophobic residues that are in the starting structure. Baker Lab scientists have cloned and expressed this protein in E. coli, but instead of aligning into well-ordered trimers, it appears to form disordered aggregates in solution. We think that this can be corrected by reducing the hydrophobic surface of the monomer subunit. Because this is uncharted territory for our score function, we're starting out with a pretty low tolerance for buried polar residues. We plan to post several of these puzzles in series—each with increased tolerance for a polar interface.
Categories: Design, Overall, Symmetry

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Comments

Joined: 10/30/2012
Groups: Beta Folders
this thing is losing 20

this thing is losing 20 points when you try and share, tried on many different computers

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons