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849a: De-novo Freestyle 34 Mutant: Hand-folding Round
Status: Closed


Name: 849a: De-novo Freestyle 34 Mutant: Hand-folding Round
Status: Closed
Created: 02/25/2014
Points: 100
Expired: 03/04/2014 - 23:00
Difficulty: Intermediate
Description: This is a shortened version of Puzzle 849b, and was originally posted in error. Since many players had invested several hours into this hand-folding puzzle before the error was caught, we are re-opening the puzzle.

This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.
Categories: Hand-Folding, Overall, Prediction

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bkoep's picture
User offline. Last seen 23 hours 11 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff
Secondary structure predictions

Here are the secondary structure predictions!
Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Alanines at residues 9 and 74 are highly predicted to be part of a sheet. However, the Alanines at residues 57-59 are predicted to be in a helix!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).


If you are a new Foldit player, please make sure you have completed all these tutorials before trying this puzzle:
- lonely sheets,
- lock and lower,
- rebuild,
- structure and rebuild,
- control over clashing.

frood66's picture
User offline. Last seen 5 hours 40 min ago. Offline
Joined: 09/20/2011
Groups: Marvin's bunch
the starting model appears to

the starting model appears to be missing the last 37 residues

bkoep's picture
User offline. Last seen 23 hours 11 min ago. Offline
Joined: 11/15/2012
Groups: Foldit Staff

Thanks for the catch, that was my mistake. I've reposted the puzzle here: http://fold.it/portal/node/997118

gitwut's picture
User offline. Last seen 2 years 42 weeks ago. Offline
Joined: 05/18/2012
Groups: Contenders
Puzzle displays as being closed, points assigned

I'm guessing that it will be corrected at some point? It looks like it's already been factored into the category scores/rankings.

beta_helix's picture
User offline. Last seen 7 hours 49 min ago. Offline
Joined: 05/09/2008
Groups: None

the current points will be removed and recalculated once that puzzle closes for good.

We apologize for the confusion with this one!

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