puzzle picture
847b: 65 Residue Dimer Design
Status: Closed


Name: 847b: 65 Residue Dimer Design
Status: Closed
Created: 02/18/2014
Points: 0
Expired: 03/26/2014 - 23:00
Difficulty: Intermediate
Description: NOTE: This is a repost of Puzzle 847, which had a minor error in the puzzle setup. You will be able to load in solutions from Puzzle 847, although you may need more a few more points than usual for your evolver score to count.

This is a symmetric dimer design puzzle with 65 residues. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment Filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!
Categories: Design, Overall, Symmetry

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Developed by: UW Center for Game Science, UW Institute for Protein Design, Northeastern University, Vanderbilt University Meiler Lab, UC Davis
Supported by: DARPA, NSF, NIH, HHMI, Amazon, Microsoft, Adobe, RosettaCommons