846: Ebola hotspot discovery
|Name:||846: Ebola hotspot discovery|
|Expired:||02/24/2014 - 23:00|
|Description:||We would like to design a peptide to treat the Ebola virus. This puzzle is a hotspot discovery puzzle, meaning that we would like you to find a good place in which to fit a small peptide "stub" in a particular hydrophobic binding pocket on the Ebola virus glycoprotein. We will then use the best stub placements as starting points for designing a larger molecule. Blocking this pocket on the Ebola glycoprotein will prevent the glycoprotein from binding to proteins on host cells, and should thereby block viral entry into host cells. We're starting you with a tryptophan, but you can mutate the stub residues to whatever you like. Remember that you can share interesting designs with the scientists, regardless your score!|
Need this puzzle? Log in to download.