Disulfide scoring term is no longer there

Case number:671071-996850
Topic:Game: Other
Opened by:Timo van der Laan
Status:Open
Type:Bug
Opened on:Thursday, February 6, 2014 - 17:07
Last modified:Thursday, February 13, 2014 - 04:43

This makes some scripts unusable, I would like to see it return.

(Thu, 02/06/2014 - 17:07  |  8 comments)


Joined: 09/21/2011
Groups: Void Crushers

Also it makes it impossible for us to see if we have the right configuration for this kind of bonds. Sometimes flipping one helps.

jflat06's picture
User offline. Last seen 17 hours 34 min ago. Offline
Joined: 09/29/2010
Groups: Window Group

Do you mean the GetSegmentEnergySubscore function is not returning a disulfide score for a cystine that is participating in a disulfide?

Joined: 09/21/2011
Groups: Void Crushers

Exactly, and also not visible in the tab segment scoring. I have deduced that it is now hidden in the other score, but that is not enough for recipes.

jeff101's picture
User offline. Last seen 1 day 18 hours ago. Offline
Joined: 04/20/2012
Groups: Go Science

I use bands to make disulfide bonds form and check with tab the disulfide energy subscore to see if these bonds have formed. Now I have to think of a new way to check if they have formed. One solution would be to make the bands invisible or transparent (see http://fold.it/portal/node/993644), but alas, that is not yet an option.

A related question is what energy subscores reflect the formation of hydrogen bonds and salt bridges. Perhaps subscores for these bonds can be listed too.

jflat06's picture
User offline. Last seen 17 hours 34 min ago. Offline
Joined: 09/29/2010
Groups: Window Group

I've found the problem. It should be fixed in the next update.

Joined: 09/21/2011
Groups: Void Crushers

I can see the scoring term is back. Is it correct that it scores now about half the points it used to do?

jeff101's picture
User offline. Last seen 1 day 18 hours ago. Offline
Joined: 04/20/2012
Groups: Go Science

I quit & restarted several Foldit clients 1100pm CST 2/9/14, 1157pm CST 2/9/14, 1225am CST 2/10/14, and 528am CST 2/12/14, but I do not see the disulfide subscores with Tab even though I have visible disulfide bonds on all clients. You can e-mail me questions to help debug this. I'm not sure what files you need for clues.

jeff101's picture
User offline. Last seen 1 day 18 hours ago. Offline
Joined: 04/20/2012
Groups: Go Science

I quit & restarted a Foldit client 757pm CST 2/12/14 and now it shows the disulfide subscore.

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