If you are new to Foldit, here are detailed instructions to get you started:
If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit:
- try all puzzles not only "beginner" ones,
- fold first the ones you like the most,
- try by yourself to understand what works and what doesn't,
- ask for tips in global when you think you doesn't understand something.
Make sure you have followed these tutorials:
- lonely sheets,
- lock and lower,
- structure and rebuild,
- control over clashing
before starting this puzzle.
Almost all of these revisiting puzzles are small, cysteine-rich puzzles. Is this because you are specifically studying the effect of having bridges enabled, or because all the original old puzzles were small, and small proteins can only be held together by bridges?