835: SOD1 Hotspot
|Name:||835: SOD1 Hotspot|
|Expired:||01/27/2014 - 20:00|
|Description:||Mutations in the gene encoding the SOD1 protein cause a subset of cases of amyotrophic lateral sclerosis, or Lou Gehrig's disease. There is some evidence that the two SOD1 subunits in the dimer separate as part of the aggregation process, so a molecule that is able to "glue" the dimer together could help to slow or halt the molecular events that lead to the disease. As a starting point for designing such a "glue", we'd like you to find good places at the interface between the SOD1 subunits to place a small, three-residue fragment. In designing the sequence of this fragment, keep in mind that hydrophobic interactions (interactions with orange residues) are much more likely to give high affinity and specificity than polar interactions (interactions with blue residues), so we recommend focusing on placing hydrophobic side-chains in the cleft between the subunits. Good luck!|
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