You forgot to mention that this puzzle REQUIRES the latest client. Older clients will give an error message and refuse to load this puzzle.
You forgot to mention that this puzzle REQUIRES the latest client. Older clients will give an error message and refuse to load this puzzle.
Ah, true -- the puzzle does require the latest version of the game. We found a few bugs that appeared with puzzles that had cutpoints in the starting configuration, so the programmers had to fix those before we released this puzzle.
Abeta backbone free?
Why is the abeta backbone free? All the other puzzles in this series have had the backbone of abeta locked.
We know that the Abeta peptide is pretty flexible in solution, and is very likely to change shape upon binding—especially if the new shape makes better interactions with the binding protein. We do expect that these changes would be small, and that the peptide will generally favor a two-stranded beta sheet.
We've tried to estimate the number of residues required to close each loop, but you may prefer to distribute these residues differently. You can delete residues from one loop and reinsert them into another, although you cannot add additional residues to this puzzle.
There is no RMSD filter for this puzzle, but there are some constraints to help keep the secondary structure pieces in place. Note also that you can wiggle the backbone of the Abeta peptide, although there are constraints to keep the two Abeta strands in a sheet.